Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.55 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.55 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.49 |
| ▸ | THRA | P10827 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2229263 | 0.91 | FOLH1 (0.57) | ALDH1A1FOLH1MCL1PTGER1KDM4E | |
| SCHEMBL15716510 | 0.90 | ALDH1A1 (0.58) | ALDH1A1NR4A2NR4A1NR4A3MEN1 | |
| SCHEMBL31354683 | 0.90 | ALDH1A1 (0.68) | ALDH1A1NR4A2NR4A1NR4A3KMT2A | |
| Hydrochloric Acid SCHEMBL514324 | 0.90 | FOLH1 (0.56) | ALDH1A1FOLH1MCL1PTGER1KDM4E | |
| SCHEMBL5280954 | 0.88 | LMNA (0.60) | ALDH1A1NR4A2NR4A1NR4A3MEN1 | |
| SCHEMBL15726040 | 0.88 | PTGER1 (0.57) | ALDH1A1NR4A2NR4A1NR4A3MEN1 | |
| SCHEMBL5557744 | 0.87 | SMN1; SMN2 (0.50) | ALDH1A1NR4A2NR4A1NR4A3MEN1 | |
| SCHEMBL11024567 | 0.86 | MCL1 (0.54) | ALDH1A1NR4A2NR4A1NR4A3MEN1 | |
| SCHEMBL6859323 | 0.86 | LMNA (0.54) | MCL1LMNAHPGDMAOBL3MBTL1 | |
| SCHEMBL28133879 | 0.86 | PDE4D (0.62) | MEN1KMT2AFOLH1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9439984-B2 | Macrocycles | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-09-13 | — | — | US | disclosed |
| US-9439984-B2 | Macrocycles | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-09-13 | — | — | US | disclosed |
| US-20150218120-A1 | HIV INTEGRASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-08-06 | — | — | US | disclosed |
| US-20150157746-A1 | MACROCYCLES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-06-11 | — | — | US | disclosed |
| US-20150157746-A1 | MACROCYCLES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-06-11 | — | — | US | disclosed |
| US-20140142137-A1 | HIV INTEGRASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH (US) | 2014-05-22 | — | — | US | disclosed |
| WO-2013187971-A2 | MACROCYCLES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-12-19 | — | — | WO | disclosed |
| WO-2012106534-A2 | HIV INTEGRASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-08-09 | — | — | WO | disclosed |
| US-7718781-B2 | Hydroxypyridonate and hydroxypyrimidinone chelating agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-05-18 | — | — | US | disclosed |
| EP-1423399-A4 | HYDROXYPYRIDONATE AND HYDROXYPYRIMIDINONE CHELATING AGENTS | UNIV CALIFORNIA (US) | 2008-05-07 | — | — | EP | disclosed |
| EP-1856046-A1 | CONJUGATES OF METAL COMPLEX HYDROXYPYRIDIN DERIVATIVES AND BIOMOLECULES AND THE USE THEREOF FOR PRODUCING AGENTS USED IN NMR DIAGNOSIS | Bayer Schering Pharma Aktiengesellschaft (DE) | 2007-11-21 | — | — | EP | disclosed |
| WO-2007121453-A2 | 2-HYDROXY-1-OXO 1,2 DIHYDRO ISOQUINOLINE CHELATING AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-10-25 | — | — | WO | disclosed |
| EP-1828129-A1 | HYDROXYPYRIDINONE DERIVATIVES, THEIR METAL COMPLEXES AND THEIR USE IN THE PRODUCTION OF CONJUGATES WITH BIOMOLECULES | Bayer Schering Pharma Aktiengesellschaft (DE) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006069678-A1 | CONJUGATES OF METAL COMPLEX HYDROXYPYRIDIN DERIVATIVES AND BIOMOLECULES AND THE USE THEREOF FOR PRODUCING AGENTS USED IN NMR DIAGNOSIS | SCHERING AG (DE) | 2006-07-06 | — | — | WO | disclosed |
| WO-2006069676-A1 | HYDROXYPYRIDINONE DERIVATIVES, THEIR METAL COMPLEXES AND THEIR USE IN THE PRODUCTION OF CONJUGATES WITH BIOMOLECULES | SCHERING AG (DE) | 2006-07-06 | — | — | WO | disclosed |
| US-6846915-B2 | Hydroxypyridonate and hydroxypyrimidinone chelating agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-01-25 | — | — | US | disclosed |
| US-20050008570-A1 | Hydroxypyridonate and hydroxypyrimidinone chelating agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-01-13 | — | — | US | disclosed |
| EP-1423399-A2 | HYDROXYPYRIDONATE AND HYDROXYPYRIMIDINONE CHELATING AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2004-06-02 | — | — | EP | disclosed |
| US-20030095922-A1 | Hydroxypyridonate and hydroxypyrimidinone chelating agents | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-05-22 | — | — | US | disclosed |
| WO-2003016923-A2 | HYDROXYPYRIDONATE AND HYDROXYPYRIMIDINONE CHELATING AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-02-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050008570-A1 | Hydroxypyridonate and hydroxypyrimidinone chelating agents | HAMP, GDI1, MPI | ALDH1A1 2521/4885NR4A2 3413/4885NR4A1 4189/4885 |
| US-20140142137-A1 | HIV INTEGRASE INHIBITORS | IMPDH1, TYMP, IMPA1 | ALDH1A1 1197/4885NR4A2 2544/4885NR4A1 2967/4885 |
| US-20150157746-A1 | MACROCYCLES | SLC39A14, SLC39A3, SLC40A1 | ALDH1A1 3621/4885NR4A2 2764/4885NR4A1 2623/4885 |
| US-20150218120-A1 | HIV INTEGRASE INHIBITORS | IMPDH1, TYMP, IMPA1 | ALDH1A1 1197/4885NR4A2 2544/4885NR4A1 2967/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.