Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 8/20 | 1.00 |
| ▸ | MGMT | P16455 | 9/20 | 0.62 |
| ▸ | CDK1 | P06493 | 7/20 | 0.60 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.60 |
| ▸ | CDK2 | P24941 | 6/20 | 0.60 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29795745 | 1.00 | PIN1 (1.00) | PIN1MGMTCDK1CCNB1CCNA2 | |
| SCHEMBL2775958 | 0.84 | PIN1 (0.73) | PIN1MGMTCDK1CCNB1CCNA2 | |
| SCHEMBL18573846 | 0.83 | PIN1 (0.71) | PIN1MGMTCDK1CCNB1CCNA2 | |
| SCHEMBL2097005 | 0.80 | PIN1 (0.67) | PIN1MGMTCDK1CCNB1CCNA2 | |
| SCHEMBL28785335 | 0.80 | PIN1 (0.66) | PIN1MGMTCDK1CCNB1CCNA2 | |
| SCHEMBL2383470 | 0.79 | PIN1 (0.66) | PIN1MGMTLMNA | |
| SCHEMBL3338895 | 0.78 | PIN1 (0.76) | PIN1MGMTCDK1CCNB1CCNA2 | |
| SCHEMBL2100316 | 0.78 | MGMT (0.63) | PIN1MGMTCDK1CCNB1CCNA2 | |
| SCHEMBL24218387 | 0.77 | PIN1 (0.70) | PIN1MGMTCDK1CCNB1CCNA2 | |
| SCHEMBL29749175 | 0.77 | MGMT (0.81) | PIN1MGMTCDK1CCNB1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230137943-A1 | PHOTOPROXIMITY PROFILING OF PROTEIN-PROTEIN INTERACTIONS IN CELLS | THE UNIVERSITY OF CHICAGO | 2023-05-04 | — | — | US | disclosed |
| CN-114728970-A | Optical proximity analysis of protein-protein interactions in cells | 芝加哥大学 | 2022-07-08 | — | — | CN | disclosed |
| WO-2021055960-A1 | PHOTOPROXIMITY PROFILING OF PROTEIN-PROTEIN INTERACTIONS IN CELLS | THE UNIVERSITY OF CHICAGO (US) | 2021-03-25 | — | — | WO | disclosed |
| US-7799524-B2 | Substrates for O6-alkylguanina-DNA alkyltransferase | Ecole Polytechnique Ferdeale de Lausanne (CH) | 2010-09-21 | — | — | US | disclosed |
| US-20060024775-A1 | Substrates for o6-alkylguanina-dna alkyltransferase | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL). (CH) | 2006-02-02 | — | — | US | disclosed |
| EP-1546371-A1 | SUBSTRATES FOR O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004031405-A1 | SUBSTRATES FOR O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2004-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060024775-A1 | Substrates for o6-alkylguanina-dna alkyltransferase | AGT, OGG1, NUDT1 | PIN1 2586/4885MGMT 18/4885CDK1 3650/4885 |
| US-20230137943-A1 | PHOTOPROXIMITY PROFILING OF PROTEIN-PROTEIN INTERACTIONS IN CELLS | PPIA, S100A4, S100A6 | PIN1 11/4885MGMT 783/4885CDK1 987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.