Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | CCR5 | P51681 | 3/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | UBE2M | P61081 | 1/20 | 0.47 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22426263 | 1.00 | OPRM1 (0.59) | OPRM1SIGMAR1CCR5HTR2ACHRM2 | |
| SCHEMBL4220408 | 0.94 | OPRM1 (0.63) | OPRM1SIGMAR1CCR5HTR2ACHRM2 | |
| Hydrochloric Acid SCHEMBL4920052 | 0.93 | OPRM1 (0.62) | OPRM1SIGMAR1CCR5HTR2ACHRM2 | |
| Oxalic Acid SCHEMBL4217435 | 0.92 | OPRM1 (0.61) | OPRM1SIGMAR1CCR5HTR2ACHRM2 | |
| SCHEMBL339807 | 0.90 | HTR2A (0.61) | OPRM1SIGMAR1CCR5HTR2ACHRM2 | |
| SCHEMBL9995041 | 0.88 | OPRM1 (0.55) | OPRM1SIGMAR1CCR5HTR2ACHRM2 | |
| SCHEMBL341425 | 0.86 | HTR2A (0.57) | OPRM1SIGMAR1CCR5HTR2ACHRM2 | |
| Hydrochloric Acid SCHEMBL4206400 | 0.86 | OPRM1 (0.77) | OPRM1CCR5HTR2A | |
| SCHEMBL340597 | 0.85 | HTR2A (0.62) | OPRM1CCR5HTR2APOLBUBE2M | |
| SCHEMBL4207777 | 0.85 | OPRM1 (0.67) | OPRM1SIGMAR1HTR2ACHRM2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140350064-A1 | PHARMACEUTICAL COMPOSITION COMPRISING AN AMPK ACTIVATOR AND A SEROTONERGIC AGENT AND METHODS OF USE THEREOF | ALS MOUNTAIN LLC | 2014-11-27 | — | — | US | claimed |
| US-20120183600-A1 | NOVEL COMPOSITION FOR TREATING METABOLIC SYNDROME AND OTHER CONDITIONS | CHEN CHIEN-HUNG (US) | 2012-07-19 | — | — | US | claimed |
| EP-1787984-A2 | AZACYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF SEROTONIN RELATED DISEASES | Arcadia Pharmaceuticals Inc. (US) | 2007-05-23 | — | — | EP | claimed |
| EP-1263729-B1 | AZACYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF SEROTONIN RELATED DISEASES | ACADIA PHARM INC (US) | 2006-12-20 | — | — | EP | claimed |
| US-20060194778-A1 | Serotonin receptor antagonist; psychological disorders; side effect reduction | ACADIA PHARMACEUTICALS, INC. | 2006-08-31 | — | — | US | claimed |
| US-20050014757-A1 | Azacyclic compounds | ANDERSSON CARL-MAGNUS A (DK) | 2005-01-20 | — | — | US | claimed |
| US-20030220316-A1 | Azacyclic compounds | ACADIA PHARMACEUTICALS INC. | 2003-11-27 | — | — | US | claimed |
| CN-1443167-A | Azacyclo compounds for the treatment of 5-hydroxytryptamine related disorders | ACADIA PHARM INC (US) | 2003-09-17 | — | — | CN | claimed |
| US-20020004513-A1 | Azacyclic compounds | ACADIA PHARMACEUTICALS INC. | 2002-01-10 | — | — | US | claimed |
| US-11840514-B2 | Catalysts and methods for enantioselective conjugate addition of amines to unsaturated electrophiles | NORTHWESTERN UNIVERSITY (US) | 2023-12-12 | — | — | US | disclosed |
| US-20210002221-A1 | CATALYSTS AND METHODS FOR ENANTIOSELECIVE CONJUGATE ADDITION OF AMINES TO UNSATURATED ELECTROPHILES | NORTHWESTERN UNIVERSITY | 2021-01-07 | — | — | US | disclosed |
| US-10781172-B2 | Catalysts and methods for enantioselective conjugate additions of amines to unsaturated electrophiles | NORTHWESTERN UNIVERSITY (US) | 2020-09-22 | — | — | US | disclosed |
| US-9765053-B2 | Methods of treatment using selective 5-HT2A inverse agonists | ACADIA PHARMACEUTICALS INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-20170165273-A9 | METHODS OF TREATMENT USING SELECTIVE 5-HT2A INVERSE AGONISTS | ANDERSSON CARL-MAGNUS A (DK) | 2017-06-15 | — | — | US | disclosed |
| US-6756393-B2 | AMIDES AND UREAS N-SUBSTITUTED WITH PIPERIDINE OR NORTROPANE; SEROTONIN INVERSE AGONISTS OR ANTAGONISTS; ANTIPSYCHOTIC | ACADIA PHARMACEUTICALS, INC. | 2004-06-29 | — | — | US | disclosed |
| US-20030220316-A1 | Azacyclic compounds | ACADIA PHARMACEUTICALS INC. | 2003-11-27 | — | — | US | disclosed |
| CN-1443167-A | Azacyclo compounds for the treatment of 5-hydroxytryptamine related disorders | ACADIA PHARM INC (US) | 2003-09-17 | — | — | CN | disclosed |
| EP-1263729-A1 | AZACYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF SEROTONIN RELATED DISEASES | Acadia Pharmaceuticals Inc. (US) | 2002-12-11 | — | — | EP | disclosed |
| US-20020004513-A1 | Azacyclic compounds | ACADIA PHARMACEUTICALS INC. | 2002-01-10 | — | — | US | disclosed |
| WO-2001066521-A1 | AZACYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF SEROTONIN RELATED DISEASES | ACADIA PHARMACEUTICALS, INC. (US) | 2001-09-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220316-A1 | Azacyclic compounds | HTR6, TPMT, HNMT | OPRM1 210/4885SIGMAR1 295/4885CCR5 935/4885 |
| US-20020004513-A1 | Azacyclic compounds | HTR6, TPMT, HNMT | OPRM1 210/4885SIGMAR1 295/4885CCR5 935/4885 |
| US-11840514-B2 | Catalysts and methods for enantioselective conjugate addition of amines to unsaturated electrophiles | AADAC, COASY, PAICS | OPRM1 1459/4885SIGMAR1 2563/4885CCR5 3037/4885 |
| US-20050014757-A1 | Azacyclic compounds | HTR6, TPMT, HNMT | OPRM1 210/4885SIGMAR1 295/4885CCR5 935/4885 |
| US-20170165273-A9 | METHODS OF TREATMENT USING SELECTIVE 5-HT2A INVERSE AGONISTS | HTR2A, HTR5A, HTR3B | OPRM1 73/4885SIGMAR1 208/4885CCR5 1962/4885 |
| US-10781172-B2 | Catalysts and methods for enantioselective conjugate additions of amines to unsaturated electrophiles | AADAC, COASY, PAICS | OPRM1 1618/4885SIGMAR1 2723/4885CCR5 3276/4885 |
| US-20060194778-A1 | Serotonin receptor antagonist; psychological disorders; side effect reduction | HTR2A, HTR1A, HTR1B | OPRM1 193/4885SIGMAR1 125/4885CCR5 2762/4885 |
| US-20210002221-A1 | CATALYSTS AND METHODS FOR ENANTIOSELECIVE CONJUGATE ADDITION OF AMINES TO UNSATURATED ELECTROPHILES | COASY, AADAC, AOC1 | OPRM1 1258/4885SIGMAR1 2141/4885CCR5 2565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.