Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 3/20 | 0.42 |
| ▸ | GABRG2 known ✓ | P18507 | 2/20 | 0.42 |
| ▸ | GABRB3 known ✓ | P28472 | 2/20 | 0.42 |
| ▸ | GABRB2 known ✓ | P47870 | 2/20 | 0.42 |
| ▸ | GABRB1 known ✓ | P18505 | 1/20 | 0.42 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.42 |
| ▸ | GABRA5 known ✓ | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 known ✓ | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.42 |
| ▸ | GABRA4 known ✓ | P48169 | 1/20 | 0.42 |
| ▸ | GABRA6 known ✓ | Q16445 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8879320 | 0.96 | HPGD (0.42) | GABRA1HPGDGABRG2GABRB3LMNA | |
| SCHEMBL8377553 | 0.80 | HPGD (0.54) | GABRA1HPGDGABRG2GABRB3LMNA | |
| SCHEMBL8879522 | 0.80 | TSHR (0.44) | HPGDTSHRKDM4EALDH1A1KMT2A | |
| SCHEMBL8879481 | 0.79 | ACE2 (0.37) | GABRA1HPGDGABRG2GABRB3LMNA | |
| SCHEMBL8882014 | 0.78 | GABRA1 (0.57) | GABRA1HPGDGABRG2GABRB3LMNA | |
| Zinc Ion SCHEMBL10763297 | 0.78 | GABRA1 (0.57) | GABRA1HPGDGABRG2GABRB3LMNA | |
| SCHEMBL8878918 | 0.78 | HPGD (0.42) | GABRA1HPGDGABRG2GABRB3LMNA | |
| SCHEMBL11216211 | 0.78 | GABRA1 (0.57) | GABRA1HPGDGABRG2GABRB3LMNA | |
| SCHEMBL1535423 | 0.75 | ALDH1A1 (0.50) | HPGDCA1CA2TSHRBLM | |
| SCHEMBL8878559 | 0.75 | KDM4E (0.56) | HPGDLMNACA1CA2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120016152-A1 | Process for the preparation of 4`-haloalkylbiphenyl-2-carboxylic acids | SALTIGO GMBH (DE) | 2012-01-19 | — | — | US | disclosed |
| EP-2366680-A2 | Method for manufacturing 4'-halogenalkyl-biphenyl-2-carboxylic acids | Saltigo GmbH (DE) | 2011-09-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120016152-A1 | Process for the preparation of 4`-haloalkylbiphenyl-2-carboxylic acids | CYP4B1, HACL2, UGT1A4 | GABRA1 238/4885GABRG2 266/4885GABRB3 201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.