Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 10/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 10/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 10/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1671484 | 0.85 | PRSS1 (0.49) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL29941779 | 0.85 | PRSS1 (0.49) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL15780787 | 0.80 | MMP12 (0.41) | PRSS1PRSS2PRSS3BACE1KCNH2 | |
| SCHEMBL8040140 | 0.78 | PRSS1 (0.41) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL3438836 | 0.78 | SMN1; SMN2 (0.54) | PRSS1PRSS2PRSS3 | |
| SCHEMBL3742950 | 0.77 | HTR2C (0.46) | — | |
| SCHEMBL12084866 | 0.77 | HTR2C (0.46) | — | |
| SCHEMBL320695 | 0.77 | OPRM1 (0.43) | PRSS1PRSS2PRSS3KCNH2 | |
| SCHEMBL14879763 | 0.77 | PRSS1 (0.41) | PRSS1PRSS2PRSS3MAOAMAOB | |
| SCHEMBL14898222 | 0.77 | PRSS1 (0.38) | PRSS1PRSS2PRSS3MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140161729-A1 | COFLUORONS AND METHODS OF MAKING AND USING THEM | CORNELL UNIVERSITY (US) | 2014-06-12 | — | — | US | disclosed |
| US-8536189-B2 | Spiropiperidines for use as tryptase inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2013-09-17 | — | — | US | disclosed |
| US-20120165327-A1 | SPIROPIPERIDINES FOR USE AS TRYPTASE INHIBITORS | COSTANZO MICHAEL J (US) | 2012-06-28 | — | — | US | disclosed |
| US-8158792-B2 | Spiropiperidines for use as tryptase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-04-17 | — | — | US | disclosed |
| US-20090163527-A1 | Spiropiperidines for use as tryptase inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165327-A1 | SPIROPIPERIDINES FOR USE AS TRYPTASE INHIBITORS | TPSAB1, TPSB2, TPSD1 | PARP1 2288/4885PRSS1 7/4885PRSS2 33/4885 |
| US-20090163527-A1 | Spiropiperidines for use as tryptase inhibitors | TPSAB1, TPSB2, TPSD1 | PARP1 2288/4885PRSS1 7/4885PRSS2 33/4885 |
| US-20140161729-A1 | COFLUORONS AND METHODS OF MAKING AND USING THEM | TNFSF11, CD14, TNFRSF1A | PARP1 2628/4885PRSS1 4125/4885PRSS2 4301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.