Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9115641 | 0.86 | MMP2 (0.41) | ALDH1A1LMNAKDM4ECYP3A4 | |
| SCHEMBL4609875 | 0.85 | LARS1 (0.43) | AAK1CYP3A4 | |
| SCHEMBL16061398 | 0.82 | REN (0.44) | OPRK1TSHR | |
| SCHEMBL23175206 | 0.80 | BACE1 (0.46) | OPRK1 | |
| SCHEMBL1404234 | 0.79 | LTA4H (0.42) | ALDH1A1LMNAKDM4ESMN1; SMN2HTT | |
| SCHEMBL6828289 | 0.78 | NAMPT (0.57) | NAMPTTDP1SLC7A5RAB9A | |
| SCHEMBL9643959 | 0.78 | OPRK1 (0.45) | NAMPTALDH1A1KDM4EOPRK1ROCK2 | |
| SCHEMBL5743374 | 0.76 | NAMPT (0.62) | NAMPTALDH1A1SLC7A5 | |
| SCHEMBL7700701 | 0.76 | NAMPT (0.62) | NAMPTALDH1A1SLC7A5 | |
| SCHEMBL3625128 | 0.72 | SLC7A5 (0.56) | OPRK1SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8632989-B1 | Mutant insulin degrading enzyme and methods of use | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2014-01-21 | — | — | US | disclosed |
| US-7807396-B2 | Insulin degrading enzyme assays for treatment of alzheimer's disease | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2010-10-05 | — | — | US | disclosed |
| CN-101321863-A | Fusion proteins with modulated plasma half-life | ASTRAZENECA AB (SE) | 2008-12-10 | — | — | CN | disclosed |
| US-20080274096-A1 | Fusion Proteins Having a Modulated Half-Life in Plasma | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | US | disclosed |
| EP-1934341-A1 | FUSION PROTEINS HAVING A MODULATED HALF-LIFE IN PLASMA | AstraZeneca AB (SE) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007040437-A1 | FUSION PROTEINS HAVING A MODULATED HALF-LIFE IN PLASMA | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |
| US-20060087736-A1 | Amyloid peptide inactivating enzyme to treat alzheimer's disease | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2006-04-27 | — | — | US | disclosed |
| WO-2003102016-A2 | AMYLOID PEPTIDE INACTIVATING ENZYME TO TREAT ALZHEIMER'S DISEASE | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2003-12-11 | — | — | WO | disclosed |
| US-20030165481-A1 | Amyloid peptide inactivating enzyme to treat Alzheimer's disease | HERSH LOUIS B (US) | 2003-09-04 | — | — | US | disclosed |
| EP-0391953-A1 | COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN | DANA FARBER CANCER INSTITUTE (US) | 1990-10-17 | — | — | EP | disclosed |
| WO-1989005353-A1 | COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN | DANA FARBER CANCER INSTITUTE (US) | 1989-06-15 | — | — | WO | disclosed |