Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | GOT1 | P17174 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MPO | P05164 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.43 |
| ▸ | ACOX1 | Q15067 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 7/20 | 0.42 |
| ▸ | KDR | P35968 | 7/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL3440667 | 0.92 | EGFR (0.43) | ALDH1A1LMNAKDM4ERAB9ATP53 | |
| SCHEMBL147684 | 0.89 | KDM4E (0.52) | ALDH1A1LMNAKDM4ERAB9ATP53 | |
| SCHEMBL31146748 | 0.89 | KDM4E (0.52) | ALDH1A1LMNAKDM4ERAB9ATP53 | |
| Hydrochloric Acid SCHEMBL3440483 | 0.87 | KDM4E (0.53) | ALDH1A1LMNAKDM4ERAB9ATP53 | |
| SCHEMBL29178078 | 0.76 | LMNA (0.44) | ALDH1A1LMNAKDM4ERAB9ATP53 | |
| Hydralazine SCHEMBL8703662 | 0.75 | ALDH1A1 (0.81) | ALDH1A1LMNAKDM4ERAB9ATP53 | |
| SCHEMBL27679087 | 0.74 | LMNA (0.38) | ALDH1A1LMNAKDM4ERAB9ATP53 | |
| SCHEMBL10906806 | 0.72 | GOT1 (0.48) | ALDH1A1LMNAKDM4ERAB9AGOT1 | |
| SCHEMBL27740679 | 0.70 | LMNA (0.46) | ALDH1A1LMNAKDM4ERAB9ATP53 | |
| SCHEMBL27740684 | 0.69 | LMNA (0.48) | ALDH1A1LMNAKDM4ERAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7807830-B2 | Manufacture of pure hydralazine salts | NAVINTA LLC (US) | 2010-10-05 | — | — | US | disclosed |
| US-20090187018-A1 | temperature-assisted dissolution of hydralazine. HCl in an aqueous solvent ( ethanol, methanol, tetrahydrofuran), treatment of the solution with a clarifying agent selected from chelating agents (EDTA), activated carbon, filtration to remove chelate compounds, cooling to precipitate hydralazine.HCl | NAVINTA LLC (US) | 2009-07-23 | — | — | US | disclosed |
| US-7531653-B2 | Manufacture of pure hydralazine salts | NAVINTA LLC (US) | 2009-05-12 | — | — | US | disclosed |
| US-20070129546-A1 | Manufacture of pure hydralazine salts | NAVINTA LLC | 2007-06-07 | — | — | US | disclosed |