Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCOLN3 | Q8TDD5 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 2/20 | 0.44 |
| ▸ | CASP7 | P55210 | 2/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3410968 | 0.83 | HDAC3 (0.52) | MCOLN3TSHRPKMPOLBPSEN1 | |
| SCHEMBL4126774 | 0.80 | ALDH1A1 (0.52) | PKMPOLBPSEN1PSEN2APH1B | |
| SCHEMBL20869728 | 0.77 | PKM (0.63) | MCOLN3TSHRPKMPOLBPSEN1 | |
| SCHEMBL10870111 | 0.76 | MCOLN3 (0.54) | MCOLN3TSHRPKMLMNAALDH1A1 | |
| SCHEMBL3441809 | 0.75 | HTR7 (0.46) | MCOLN3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL31107095 | 0.73 | CASP3 (0.66) | MCOLN3TSHRLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL2977241 | 0.72 | ALDH1A1 (0.61) | MCOLN3TSHRLMNAALDH1A1HCRTR1 | |
| SCHEMBL2977236 | 0.72 | ALDH1A1 (0.61) | MCOLN3TSHRLMNAALDH1A1HCRTR1 | |
| SCHEMBL3441934 | 0.72 | HTR7 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10205614 | 0.72 | PKM (0.44) | MCOLN3TSHRPKMLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2260043-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal Gmbh (DE) | 2010-12-15 | — | — | EP | claimed |
| WO-2009124746-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2009-10-15 | — | — | WO | claimed |