Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34461758 | 0.89 | TRPA1 (0.45) | TRPA1KMT2AKDRKDM4ETP53 | |
| SCHEMBL34461723 | 0.85 | TRPA1 (0.42) | TRPA1MEN1KMT2AKDRKDM4E | |
| SCHEMBL34461737 | 0.85 | TRPA1 (0.41) | TRPA1KDRKDM4ETP53MAPT | |
| SCHEMBL34461744 | 0.83 | ALDH1A1 (0.37) | ALDH1A1CYP1A2CYP3A4CYP2C19HTT | |
| SCHEMBL34461735 | 0.83 | TRPA1 (0.42) | TRPA1MEN1KMT2AKDRKDM4E | |
| SCHEMBL34461733 | 0.79 | ADORA2A (0.38) | MAPTALDH1A1CYP1A2POLBCYP3A4 | |
| SCHEMBL34461734 | 0.79 | ALDH1A1 (0.36) | KMT2AMAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL34461717 | 0.76 | TRPA1 (0.42) | TRPA1KDRKDM4ETP53MAPT | |
| SCHEMBL34461736 | 0.74 | MEN1 (0.40) | TRPA1MEN1KMT2AKDRKDM4E | |
| SCHEMBL34461739 | 0.74 | TRPA1 (0.43) | TRPA1MEN1KMT2AKDRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260098041-A1 | FUSED BICYCLIC PYRIMIDONES AS WRN INHIBITORS | INCYTE CORPORATION (US) | 2026-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260098041-A1 | FUSED BICYCLIC PYRIMIDONES AS WRN INHIBITORS | WRN, POLR1A, REV1 | TRPA1 3662/4885MEN1 897/4885KMT2A 3313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.