Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.37 |
| ▸ | GRIK2 | Q13002 | 4/20 | 0.37 |
| ▸ | GRIK3 | Q13003 | 4/20 | 0.37 |
| ▸ | GRIK5 | Q16478 | 4/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 3/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.37 |
| ▸ | GRIK4 | Q16099 | 3/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.34 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34461734 | 0.87 | ALDH1A1 (0.36) | ALDH1A1ADORA2AHTTLMNACYP1A2 | |
| SCHEMBL34461733 | 0.87 | ADORA2A (0.38) | ALDH1A1ADORA2AHTTLMNACYP1A2 | |
| SCHEMBL34461722 | 0.83 | TRPA1 (0.43) | ALDH1A1HTTCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL34461729 | 0.83 | ALDH1A1 (0.35) | ALDH1A1ADORA2ALMNA | |
| SCHEMBL34461724 | 0.82 | GRIK1 (0.39) | ALDH1A1GRIK1GRIK2GRIK3GRIK5 | |
| SCHEMBL34461758 | 0.70 | TRPA1 (0.45) | LMNA | |
| SCHEMBL34461790 | 0.70 | HCAR1 (0.33) | ALDH1A1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL34461772 | 0.69 | CYP1A2 (0.35) | ALDH1A1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL34461745 | 0.67 | ADORA2A (0.41) | ALDH1A1GRIK1GRIK2GRIK3GRIK5 | |
| SCHEMBL260928 | 0.63 | APEX1 (0.57) | GRIK1GRIK2GRIK3GRIK5GRIA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260098041-A1 | FUSED BICYCLIC PYRIMIDONES AS WRN INHIBITORS | INCYTE CORPORATION (US) | 2026-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260098041-A1 | FUSED BICYCLIC PYRIMIDONES AS WRN INHIBITORS | WRN, POLR1A, REV1 | ALDH1A1 1354/4885GRIK1 2336/4885GRIK2 4306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.