SCHEMBL3446333

SCHEMBL3446333

O=S(=O)(c1ccc(Cl)cc1)c1ccccc1F

nearest known ligand 0.58

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 7/20 0.58
ALDH1A1 P00352 1/20 0.56
CYP3A4 P08684 1/20 0.56
MAPK1 P28482 1/20 0.56
HSD11B1 P28845 2/20 0.55
CNR2 P34972 5/20 0.53
CYP2C9 P11712 1/20 0.50
HTR2C P28335 1/20 0.49
HTR2B P41595 1/20 0.49
ABCC9 O60706 1/20 0.48
ABCC8 Q09428 1/20 0.48
KCNJ11 Q14654 1/20 0.48
KCNJ8 Q15842 1/20 0.48
HTR2A P28223 1/20 0.48
KDM4E B2RXH2 1/20 0.47
PKM P14618 1/20 0.47
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10869745 0.86 ALDH1A1 (0.68) ALDH1A1CYP3A4MAPK1HSD11B1CNR2
SCHEMBL2474755 0.84 HTR2A (0.59) CNR1HSD11B1CNR2HTR2CHTR2B
SCHEMBL776706 0.84 HTR6 (0.57) CNR1HSD11B1CNR2HTR2CHTR2B
SCHEMBL29058018 0.81 ALDH1A1 (0.47) CNR1ALDH1A1CYP3A4MAPK1HSD11B1
SCHEMBL8866512 0.81 HTR6 (0.59) CNR1ALDH1A1CYP3A4HSD11B1CNR2
SCHEMBL13343182 0.81 CNR1 (0.58) CNR1CNR2CYP2C9
SCHEMBL2305468 0.80 TSHR (0.45) CNR1ALDH1A1CYP3A4MAPK1HSD11B1
SCHEMBL2034446 0.80 HSD11B1 (0.68) ALDH1A1CYP3A4MAPK1HSD11B1CNR2
SCHEMBL2947083 0.80 ALDH1A1 (0.60) ALDH1A1CYP3A4MAPK1HSD11B1CNR2
SCHEMBL29057982 0.80 ALDH1A1 (0.46) CNR1ALDH1A1CYP3A4MAPK1HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7816053-B2 Membrane-electrode assembly for solid polymer electrolyte fuel cell HONDA MOTOR CO., LTD. (JP) 2010-10-19 US disclosed
US-20060280991-A1 Membrane-electrode assembly for solid polymer electrolyte fuel cell HONDA MOTOR CO., LTD. 2006-12-14 US disclosed
US-6451921-B2 Block copolymers with sulfonated polyether sulfone units MEMBRANA GMBH (DE) 2002-09-17 US disclosed
US-20010021764-A1 Block copolymers with sulfonated polyether sulfone units MEMBRANA GMBH (DE) 2001-09-13 US disclosed