Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | CNR1 | P21554 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HBB | P68871 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MPI | P34949 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3450024 | 0.80 | SMN1; SMN2 (0.47) | SMN1; SMN2CNR1CNR2TSHRCYP2C19 | |
| SCHEMBL3449664 | 0.75 | MKNK1 (0.39) | SMN1; SMN2CNR1CNR2CYP1A2CYP2D6 | |
| SCHEMBL3343275 | 0.75 | CNR2 (0.65) | SMN1; SMN2CNR1CNR2TSHRCYP1A2 | |
| SCHEMBL3449342 | 0.73 | LMNA (0.51) | SMN1; SMN2CNR1TSHRCYP1A2CYP2D6 | |
| SCHEMBL3378730 | 0.68 | SMN1; SMN2 (0.67) | SMN1; SMN2CNR1CNR2TSHRCYP1A2 | |
| SCHEMBL4250096 | 0.68 | ALDH1A1 (0.52) | SMN1; SMN2LMNAKMT2AALDH1A1MAPT | |
| SCHEMBL19172634 | 0.67 | SMN1; SMN2 (0.47) | SMN1; SMN2CNR1CNR2TSHRPOLB | |
| SCHEMBL3348287 | 0.66 | CNR2 (0.43) | SMN1; SMN2CNR1CNR2CYP2C19LMNA | |
| SCHEMBL19959641 | 0.65 | POLB (0.47) | SMN1; SMN2TSHRPOLBKMT2AALDH1A1 | |
| SCHEMBL4639541 | 0.65 | MEN1 (0.49) | CNR1CNR2POLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | SDHA, SDHB, UROD | SMN1; SMN2 3328/4885CNR1 653/4885CNR2 517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.