Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 4/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.37 |
| ▸ | RELA | Q04206 | 4/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5634238 | 1.00 | NFKB1 (0.37) | NFKB1NFKB2RELANLRP3 | |
| SCHEMBL968867 | 0.81 | NFKB1 (0.38) | NFKB1NFKB2RELA | |
| SCHEMBL968866 | 0.81 | NFKB1 (0.38) | NFKB1NFKB2RELA | |
| SCHEMBL852586 | 0.81 | NFKB1 (0.38) | NFKB1NFKB2RELA | |
| SCHEMBL14209522 | 0.76 | — | — | |
| SCHEMBL13940276 | 0.76 | — | — | |
| SCHEMBL13497462 | 0.75 | — | — | |
| SCHEMBL8577970 | 0.71 | NFKB1 (0.46) | NFKB1NFKB2RELA | |
| SCHEMBL2816076 | 0.69 | NFKB1 (0.49) | NFKB1NFKB2RELANLRP3 | |
| SCHEMBL2816078 | 0.69 | NFKB1 (0.49) | NFKB1NFKB2RELANLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100041918-A1 | CYCLOPENTENE DIOL MONOACETATE DERIVATIVES | NOVARTIS AG | 2010-02-18 | — | — | US | disclosed |
| US-20100041918-A1 | CYCLOPENTENE DIOL MONOACETATE DERIVATIVES | NOVARTIS AG | 2010-02-18 | — | — | US | disclosed |
| EP-2084121-A1 | CYCLOPENTENE DIOL MONOACETATE DERIVATIVES | Novartis AG (CH) | 2009-08-05 | — | — | EP | disclosed |
| WO-2008055874-A1 | CYCLOPENTENE DIOL MONOACETATE DERIVATIVES | NOVARTIS AG (CH) | 2008-05-15 | — | — | WO | disclosed |
| US-7220870-B2 | Hydrolytic kinetic resolution of cyclic substrates | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-05-22 | — | — | US | disclosed |
| EP-0817765-B1 | STEREOSELECTIVE RING OPENING REACTIONS | HARVARD COLLEGE (US) | 2006-02-01 | — | — | EP | disclosed |
| US-20050187392-A1 | Hydrolytic kinetic resolution of cyclic substrates | HARVARD UNIVERSITY (US) | 2005-08-25 | — | — | US | disclosed |
| US-6841667-B2 | Nucleophilic kinetic resolution of cyclic substrates using silyl azides | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2005-01-11 | — | — | US | disclosed |
| US-6800766-B2 | CATALYZING THE DECYCLIZATION OF RACEMIC AND DIASTEREOMERIC EPOXIDES MIXTURES IN THE PRESENCE OF A NON-RACEMIC, CHIRAL CATALYST; PHARMACEUTICAL SYNTHESIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2004-10-05 | — | — | US | disclosed |
| US-20040044233-A1 | Nucleophilic kinetic resolution of cyclic substrates using silyl azides | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-03-04 | — | — | US | disclosed |
| US-20030139614-A1 | Hydrolytic kinetic resolution of cyclic substrates | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2003-07-24 | — | — | US | disclosed |
| US-6448414-B1 | ENANTIOMERICALLY PURE COMPOUNDS BY REACTING WATER AND CARBOCYCLE OR HETEROCYCLE HAVING AN ELECTROPHILIC CENTER IN THE PRESENCE OF AN ASYMMETRIC TETRADENTATE LIGAND COMPLEXED WITH A METAL ATOM, WHICH HAS A GEOMETRIC SHAPE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2002-09-10 | — | — | US | disclosed |
| US-20020032338-A1 | Hydrolytic kinetic resolution of cyclic substrates | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2002-03-14 | — | — | US | disclosed |
| US-6262278-B1 | REACTING WATER AND MIXTURE OF STEREOISOMERS OF CHIRAL CYCLIC SUBSTRATE IN THE PRESENCE OF NON-RACEMIC CHIRAL CATALYST TO PRODUCE BY KINETIC RESOLUTION STEREOISOMERICALLY ENRICHED CYCLIC SUBSTRATE OR STEREOISOMERICALLY ENRICHED HYDROLYZATE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2001-07-17 | — | — | US | disclosed |
| EP-1104395-A1 | STEREOSELECTIVE RING OPENING REACTIONS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2001-06-06 | — | — | EP | disclosed |
| WO-2000009463-A1 | STEREOSELECTIVE RING OPENING REACTIONS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2000-02-24 | — | — | WO | disclosed |
| US-5929232-A | REACTING NUCLEOPHILE AND RACEMIC MIXTURE OF CHIRAL CYCLIC SUBSTRATE IN PRESENCE OF NON-RACEMIC CHIRAL CATALYST TO PRODUCE STEREOISOMERICALLY ENRICHED CYCLIC SUBSTRATE BY KINETIC RESOLUTION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1999-07-27 | — | — | US | disclosed |
| EP-0817765-A1 | STEREOSELECTIVE RING OPENING REACTIONS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1998-01-14 | — | — | EP | disclosed |
| WO-1996028402-A1 | STEREOSELECTIVE RING OPENING REACTIONS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1996-09-19 | — | — | WO | disclosed |
| US-4228298-A | 15-Deoxy-16-hydroxy-16-fluoromethyl, difluoromethyl or trifluoromethyl prostaglandins of the E and F series | AMERICAN CYANAMID COMPANY (US) | 1980-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030139614-A1 | Hydrolytic kinetic resolution of cyclic substrates | EPHX2, EPHX1, APEH | NFKB1 1212/4885NFKB2 2508/4885RELA 3651/4885 |
| US-20050187392-A1 | Hydrolytic kinetic resolution of cyclic substrates | EPHX2, EPHX1, APEH | NFKB1 1212/4885NFKB2 2508/4885RELA 3651/4885 |
| US-20040044233-A1 | Nucleophilic kinetic resolution of cyclic substrates using silyl azides | SAMHD1, PCNA, ESD | NFKB1 1518/4885NFKB2 3175/4885RELA 3731/4885 |
| US-20020032338-A1 | Hydrolytic kinetic resolution of cyclic substrates | EPHX2, EPHX1, APEH | NFKB1 1212/4885NFKB2 2508/4885RELA 3651/4885 |
| US-20100041918-A1 | CYCLOPENTENE DIOL MONOACETATE DERIVATIVES | ADH1A, CYP1B1, CYP1A2 | NFKB1 1152/4885NFKB2 1478/4885RELA 1173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.