Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9320042 | 0.83 | GSTO1 (0.55) | TSHRSMN1; SMN2ALDH1A1MAPTCNR1 | |
| SCHEMBL16345591 | 0.82 | LMNA (0.54) | LMNATSHRSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL1592716 | 0.82 | ALDH1A1 (0.61) | LMNASMN1; SMN2ALDH1A1MAPTCNR1 | |
| SCHEMBL1913783 | 0.82 | ACHE (0.49) | LMNASMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL17774646 | 0.81 | MAPT (0.60) | TSHRSMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL10126715 | 0.79 | ALDH1A1 (0.66) | LMNATSHRSMN1; SMN2ALDH1A1CNR1 | |
| SCHEMBL23847020 | 0.78 | ALDH1A1 (0.63) | LMNATSHRALDH1A1NPC1KMT2A | |
| SCHEMBL17774640 | 0.78 | ALDH1A1 (0.45) | LMNATSHRSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4717858 | 0.78 | LMNA (0.70) | LMNATSHRSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL30511773 | 0.78 | ALDH1A1 (0.63) | LMNATSHRALDH1A1NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | SDHA, SDHB, UROD | LMNA 1717/4885TSHR 4310/4885SMN1; SMN2 3328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.