Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 6/20 | 0.50 |
| ▸ | CA9 | Q16790 | 6/20 | 0.50 |
| ▸ | CA4 | P22748 | 5/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 7/20 | 0.46 |
| ▸ | MAOB | P27338 | 7/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9503476 | 0.94 | CA12 (0.46) | CA12CA9CA4CA2CA1 | |
| SCHEMBL5704167 | 0.84 | CA12 (0.63) | CA12CA9CA4CA2CA1 | |
| SCHEMBL31725844 | 0.83 | CA12 (0.53) | CA12CA9CA4CA2CA1 | |
| Hydrochloric Acid SCHEMBL21694040 | 0.82 | CA12 (0.61) | CA12CA9CA4CA2CA1 | |
| SCHEMBL9156553 | 0.81 | CA12 (0.52) | CA12CA9CA4CA2CA1 | |
| SCHEMBL634485 | 0.79 | FFAR1 (0.38) | MAOBCYP19A1HSD17B10 | |
| SCHEMBL7381752 | 0.79 | CA12 (0.50) | CA12CA9CA4CA2CA1 | |
| SCHEMBL3677826 | 0.79 | GSTP1 (0.55) | CA12CA9CA4CA2CA1 | |
| SCHEMBL19616328 | 0.79 | CA12 (0.50) | CA12CA9CA4CA2CA1 | |
| SCHEMBL11957426 | 0.79 | CA12 (0.55) | CA12CA9CA4CA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10953369-B2 | Spirocentric compounds and polymers thereof | GEORGIA TECH RESEARCH CORPORATION (US) | 2021-03-23 | — | — | US | disclosed |
| US-10926226-B2 | Functionalized membranes and methods of production thereof | ExxonMobil Research & Engineering Company Company (US) | 2021-02-23 | — | — | US | disclosed |
| EP-3762391-A1 | SPIROCENTRIC COMPOUNDS AND POLYMERS THEREOF | ExxonMobil Research and Engineering Company (US) | 2021-01-13 | — | — | EP | disclosed |
| WO-2019173646-A1 | SPIROCENTRIC COMPOUNDS AND POLYMERS THEREOF | EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) | 2019-09-12 | — | — | WO | disclosed |
| US-20190275469-A1 | Functionalized Membranes and Methods of Production Thereof | GEORGIA TECH RESEARCH CORPORATION | 2019-09-12 | — | — | US | disclosed |
| US-20190276454-A1 | Spirocentric Compounds and Polymers Thereof | GEORGIA TECH RESEARCH CORPORATION | 2019-09-12 | — | — | US | disclosed |
| US-7820818-B2 | Heteroaryl nitrile derivatives | NOVARTIS AG (CH) | 2010-10-26 | — | — | US | disclosed |
| US-20090227596-A1 | HETEROARYL NITRILE DERIVATIVES | NOVARTIS AG (CH) | 2009-09-10 | — | — | US | disclosed |
| US-7544688-B2 | Hetereoaryl nitrile derivatives | NOVARTIS AG (CH) | 2009-06-09 | — | — | US | disclosed |
| EP-1537111-B1 | HETEREOARYL NITRILE DERIVATIVES | NOVARTIS AG (CH) | 2007-05-02 | — | — | EP | disclosed |
| US-20060142575-A1 | Hetereoaryl nitrile derivatives | NOVARTIS AG (CH) | 2006-06-29 | — | — | US | disclosed |
| EP-1537111-A1 | HETEREOARYL NITRILE DERIVATIVES | Novartis AG (CH) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004020441-A1 | HETEREOARYL NITRILE DERIVATIVES | NOVARTIS AG (CH) | 2004-03-11 | — | — | WO | disclosed |
| EP-0748159-A4 | INSECTICIDAL N-(SUBSTITUTED ARYLMETHYL)-4- BIS(SUBSTITUTED PHENYL)METHYL]PIPERIDINES | FMC CORP (US) | 1997-11-19 | — | — | EP | disclosed |
| US-5639763-A | FOR AGRICULTURAL APPLICATIONS | FMC CORPORATION (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0748159-A1 | INSECTICIDAL N-(SUBSTITUTED ARYLMETHYL)-4- BIS(SUBSTITUTED PHENYL)METHYL]PIPERIDINES | FMC CORPORATION (US) | 1996-12-18 | — | — | EP | disclosed |
| US-5569664-A | AGRICULTURAL INSECTICIDES | FMC CORPORATION (US) | 1996-10-29 | — | — | US | disclosed |
| WO-1995023507-A1 | INSECTICIDAL N-(SUBSTITUTED ARYLMETHYL)-4-[BIS(SUBSTITUTED PHENYL)METHYL]PIPERIDINES | FMC CORPORATION (US) | 1995-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190276454-A1 | Spirocentric Compounds and Polymers Thereof | PKD1, PKD2, VIM | CA12 1262/4885CA9 1424/4885CA4 1744/4885 |
| US-10926226-B2 | Functionalized membranes and methods of production thereof | LNPK, PLA2G2A, EPCAM | CA12 476/4885CA9 1737/4885CA4 1346/4885 |
| US-10953369-B2 | Spirocentric compounds and polymers thereof | PKD1, PKD2, VIM | CA12 1262/4885CA9 1424/4885CA4 1744/4885 |
| US-20090227596-A1 | HETEROARYL NITRILE DERIVATIVES | CTSK, CTSS, CTSZ | CA12 3291/4885CA9 870/4885CA4 509/4885 |
| US-20060142575-A1 | Hetereoaryl nitrile derivatives | CTSK, CTSZ, CTSE | CA12 2378/4885CA9 814/4885CA4 481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.