Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
| ▸ | PSIP1 | O75475 | 2/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
| ▸ | MLNR | O43193 | 4/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | PNMT | P11086 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 2/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | CHUK | O15111 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3454488 | 0.75 | CNR2 (0.34) | HTR6RORCPSIP1PLATMLNR | |
| SCHEMBL22324769 | 0.73 | SLC18A3 (0.48) | HTR6GAARORCPSIP1 | |
| SCHEMBL3454570 | 0.73 | NMT1 (0.33) | HTR6PLAT | |
| SCHEMBL3454494 | 0.72 | GABRA2 (0.33) | HTR6RORCPLATJAK2 | |
| SCHEMBL3455672 | 0.70 | LRRK2 (0.39) | JAK2 | |
| SCHEMBL3072064 | 0.69 | SYK (0.44) | HTR6RORCPLATMLNRCYP2D6 | |
| SCHEMBL3456235 | 0.68 | GPR119 (0.36) | — | |
| SCHEMBL4777240 | 0.65 | GBA1 (0.54) | HTR6GAARORCPSIP1MLNR | |
| Hydrochloric Acid SCHEMBL4773264 | 0.64 | GBA1 (0.53) | HTR6GAARORCPSIP1MLNR | |
| SCHEMBL3454502 | 0.62 | PSIP1 (0.34) | GAAPSIP1MLNRCYP2D6JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166850-A1 | NEW HETEOCYCLIC H3 ANTAGONISTS | High Point Pharmaceuticals, LLC (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154126-A1 | NEW HETEOCYCLIC H3 ANTAGONISTS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2008-12-18 | — | — | WO | disclosed |