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SCHEMBL3457263

SCHEMBL3457263

C=CCOC(=O)O[C@H]1C[C@H](C(=O)O)[C@@H](C(=O)N2CCN(c3ccccc3)CC2)N(C(=O)O)C1

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ ADAM10 O14672 14/20 0.49
▸ ERBB2 P04626 13/20 0.49
▸ MMP2 P08253 12/20 0.49
▸ MMP3 P08254 7/20 0.45
▸ MMP9 P14780 7/20 0.45
▸ MEN1 O00255 1/20 0.43
▸ KMT2A Q03164 1/20 0.43
▸ SIGMAR1 Q99720 1/20 0.40
▸ LMNA P02545 2/20 0.39
▸ RAB9A P51151 2/20 0.39
▸ MAPK1 P28482 2/20 0.39
▸ TFPI2 P48307 1/20 0.37
▸ MAPT P10636 2/20 0.37
▸ POLB P06746 1/20 0.37
▸ TSHR P16473 1/20 0.37
▸ HTT P42858 1/20 0.37
▸ PKM P14618 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3457135 0.90 ADAM10 (0.47) ADAM10ERBB2MMP2MMP3MMP9
SCHEMBL4558713 0.90 ADAM10 (0.47) ADAM10ERBB2MMP2MMP3MMP9
SCHEMBL2172754 0.85 ADAM10 (0.61) ADAM10ERBB2MMP2MMP3MMP9
SCHEMBL3457310 0.81 ADAM10 (0.56) ADAM10ERBB2MMP2MMP3MMP9
SCHEMBL3456887 0.81 ADAM10 (0.59) ADAM10ERBB2MMP2MMP3MMP9
SCHEMBL2173077 0.81 ADAM10 (0.52) ADAM10ERBB2MMP2MMP3MMP9
SCHEMBL3458128 0.79 ADAM10 (0.52) ADAM10ERBB2MMP2MMP3MMP9
SCHEMBL3457777 0.78 ADAM10 (0.51) ADAM10ERBB2MMP2MMP3MMP9
SCHEMBL3457966 0.78 ADAM10 (0.53) ADAM10ERBB2MMP2MMP3MMP9
SCHEMBL3457502 0.77 ADAM10 (0.53) ADAM10ERBB2MMP2MMP3MMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150025056-A1 SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES INCYTE CORPORATION (US) 2015-01-22 — — US disclosed
US-8853243-B2 Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases INCYTE CORPORATION (US) 2014-10-07 — — US disclosed
EP-2264030-A1 Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases Incyte Corporation (US) 2010-12-22 — — EP disclosed
US-20080167288-A1 Substituted cyclic hydroxamates as lnhibitors of matrix metalloproteinases LNCYTE CORPORATION (US) 2008-07-10 — — US disclosed
EP-1678167-A1 SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES Incyte Corporation (US) 2006-07-12 — — EP disclosed
WO-2005037826-A1 SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES INCYTE CORPORATION (US) 2005-04-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150025056-A1 SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES MMP25, MMP2, MMP14 ADAM10 26/4885ERBB2 3036/4885MMP2 2/4885
US-20080167288-A1 Substituted cyclic hydroxamates as lnhibitors of matrix metalloproteinases MMP25, MMP9, MMP24 ADAM10 25/4885ERBB2 3033/4885MMP2 5/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.