SCHEMBL3457775

SCHEMBL3457775

CC(C)[C@@H]1CC[C@@H](C)C[C@@]1(CCc1ccccn1)C([NH])=O

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.40
CYP1A2 P05177 1/20 0.39
TSHR P16473 2/20 0.38
HTT P42858 1/20 0.38
ATM Q13315 1/20 0.38
ALDH1A1 P00352 4/20 0.37
HPGD P15428 1/20 0.37
RECQL P46063 1/20 0.37
TAS1R3 Q7RTX0 1/20 0.36
TAS1R1 Q7RTX1 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
P2RX7 Q99572 1/20 0.36
CYP3A4 P08684 1/20 0.36
LMNA P02545 1/20 0.36
TDP1 Q9NUW8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29657487 0.89 SMN1; SMN2 (0.40) HSD11B1SMN1; SMN2CYP1A2TSHRHTT
SCHEMBL29141636 0.83 HSD11B1 (0.52) HSD11B1SMN1; SMN2CYP1A2TSHRHTT
SCHEMBL29112392 0.79 HSD11B1 (0.54) HSD11B1SMN1; SMN2CYP1A2TSHRHTT
SCHEMBL24540861 0.79 HSD11B1 (0.54) HSD11B1SMN1; SMN2CYP1A2TSHRHTT
SCHEMBL29112390 0.79 HSD11B1 (0.54) HSD11B1SMN1; SMN2CYP1A2TSHRHTT
SCHEMBL20815347 0.75 SMN1; SMN2 (0.40) HSD11B1SMN1; SMN2CYP1A2HTTATM
SCHEMBL1255783 0.70 HSD11B1 (0.46) HSD11B1SMN1; SMN2CYP1A2TSHRHTT
SCHEMBL15649538 0.68 HSD11B1 (0.54) HSD11B1SMN1; SMN2CYP1A2TSHRHTT
SCHEMBL3614438 0.68 HSD11B1 (0.56) HSD11B1SMN1; SMN2CYP1A2TSHRHTT
SCHEMBL1857057 0.66 TRPM8 (0.46) HSD11B1SMN1; SMN2CYP1A2ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2265246-A1 PREPARATIONS FOR REDUCING ITCHING AND OTHER PARAESTHESIAS WHICH WITH (1R,2S,5R)-2-ISOPROPYL-5-METHYL-N-(2-(PYRIDIN-2YL)ETHYLCYCLOHEXYL CARBOXAMIDE AND/OR (1R,2S,5R)-N84-(CYANOMETHYL)-PHENYL)-2-ISOPROPYL-5-METHYLCYCLOHEXYL CARBOXAMIDE Beiersdorf AG (DE) 2010-12-29 EP disclosed
WO-2009127282-A1 PREPARATIONS FOR REDUCING ITCHING AND OTHER PARAESTHESIAS WHICH WITH (1R,2S,5R)-2-ISOPROPYL-5-METHYL-N-(2-(PYRIDIN-2YL)ETHYLCYCLOHEXYL CARBOXAMIDE AND/OR (1R,2S,5R)-N84-(CYANOMETHYL)-PHENYL)-2-ISOPROPYL-5-METHYLCYCLOHEXYL CARBOXAMIDE BEIERSDORF AG (DE) 2009-10-22 WO disclosed