Sugi Predict

Sugi Predict / Compounds / SCHEMBL3458092

SCHEMBL3458092

SCHEMBL3458092

CO[C@@H]1CN[C@H](C(=O)N2CCN(c3ccccc3)CC2)[C@@H](C(=O)O)C1

nearest known ligand 0.60

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ ADAM10 O14672 13/20 0.60
▸ ERBB2 P04626 13/20 0.60
▸ MMP2 P08253 12/20 0.52
▸ SIGMAR1 Q99720 1/20 0.48
▸ MMP9 P14780 7/20 0.47
▸ TFPI2 P48307 1/20 0.44
▸ MMP3 P08254 6/20 0.43
▸ MAPT P10636 2/20 0.43
▸ HTT P42858 2/20 0.43
▸ LMNA P02545 1/20 0.43
▸ POLB P06746 1/20 0.43
▸ TSHR P16473 1/20 0.43
▸ RAB9A P51151 1/20 0.43
▸ ALDH1A1 P00352 2/20 0.42
▸ KMT2A Q03164 2/20 0.42
▸ DPP4 P27487 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2173637 0.91 ADAM10 (0.61) ADAM10ERBB2MMP2SIGMAR1MMP9
SCHEMBL2173645 0.88 ADAM10 (0.57) ADAM10ERBB2MMP2SIGMAR1MMP9
SCHEMBL3457134 0.88 ADAM10 (0.57) ADAM10ERBB2MMP2SIGMAR1MMP9
SCHEMBL2173246 0.81 ADAM10 (0.57) ADAM10ERBB2MMP2SIGMAR1MMP9
SCHEMBL3458731 0.78 ADAM10 (0.72) ADAM10ERBB2MMP2MMP9MMP3
SCHEMBL2175909 0.78 ADAM10 (0.72) ADAM10ERBB2MMP2MMP9MMP3
SCHEMBL27672089 0.78 ADAM10 (0.54) ADAM10ERBB2MMP2SIGMAR1MMP9
SCHEMBL2173640 0.77 ADAM10 (0.63) ADAM10ERBB2MMP2SIGMAR1MMP9
SCHEMBL3458419 0.77 ADAM10 (0.50) ADAM10ERBB2MMP2SIGMAR1MMP9
SCHEMBL3457310 0.76 ADAM10 (0.56) ADAM10ERBB2MMP2SIGMAR1MMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150025056-A1 SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES INCYTE CORPORATION (US) 2015-01-22 — — US disclosed
US-8853243-B2 Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases INCYTE CORPORATION (US) 2014-10-07 — — US disclosed
EP-2264030-A1 Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases Incyte Corporation (US) 2010-12-22 — — EP disclosed
US-20080167288-A1 Substituted cyclic hydroxamates as lnhibitors of matrix metalloproteinases LNCYTE CORPORATION (US) 2008-07-10 — — US disclosed
EP-1678167-A1 SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES Incyte Corporation (US) 2006-07-12 — — EP disclosed
WO-2005037826-A1 SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES INCYTE CORPORATION (US) 2005-04-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150025056-A1 SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES MMP25, MMP2, MMP14 ADAM10 26/4885ERBB2 3036/4885MMP2 2/4885
US-20080167288-A1 Substituted cyclic hydroxamates as lnhibitors of matrix metalloproteinases MMP25, MMP9, MMP24 ADAM10 25/4885ERBB2 3033/4885MMP2 5/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.