Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.31 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.31 |
| ▸ | SPR | P35270 | 2/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.31 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3459213 | 0.86 | KDM5A (0.38) | DHODHRECQLALDH1A1TDP1KDM4E | |
| SCHEMBL3460245 | 0.84 | DHODH (0.41) | DHODHRECQLALDH1A1TDP1KDM4E | |
| SCHEMBL3222485 | 0.81 | DHODH (0.40) | DHODHRECQLALDH1A1TDP1KDM4E | |
| SCHEMBL8886936 | 0.73 | DHODH (0.42) | DHODHRECQLALDH1A1KDM4EALOX15 | |
| SCHEMBL3458365 | 0.73 | DHODH (0.36) | DHODHRECQLALDH1A1TDP1PARP1 | |
| SCHEMBL3458154 | 0.71 | DHODH (0.35) | DHODHPARP1SPR | |
| SCHEMBL3458495 | 0.71 | DHODH (0.40) | DHODHRECQLALDH1A1TDP1KDM4E | |
| SCHEMBL1892990 | 0.69 | ALDH1A1 (0.43) | DHODHRECQLALDH1A1TDP1KDM4E | |
| SCHEMBL2963896 | 0.69 | HSP90AB1 (0.35) | DHODHALDH1A1KMT2APARP1L3MBTL1 | |
| SCHEMBL7374036 | 0.68 | KDM4E (0.37) | ALDH1A1KDM4EKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140038955-A1 | HETEROARYL AMIDE ANALOGUES AS P2X7 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2014-02-06 | — | — | US | disclosed |
| US-8580812-B2 | Heteroaryl amide analogues as P2X7 antagonists | H. LUNDBECK A/S (DK) | 2013-11-12 | — | — | US | disclosed |
| EP-2592082-A1 | Heteroaryl amide analogues as p2x7 antagonists | H. Lundbeck A/S (DK) | 2013-05-15 | — | — | EP | disclosed |
| US-20100266509-A1 | HETEROARYL AMIDE ANALOGUES AS P2X7 ANTAGONISTS | H. Lindbeck A/S (DK) | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100266509-A1 | HETEROARYL AMIDE ANALOGUES AS P2X7 ANTAGONISTS | P2RX7, P2RX3, P2RX2 | DHODH 3234/4885RECQL 1173/4885ALDH1A1 2338/4885 |
| US-20140038955-A1 | HETEROARYL AMIDE ANALOGUES AS P2X7 ANTAGONISTS | P2RX7, P2RX3, P2RX2 | DHODH 3303/4885RECQL 1340/4885ALDH1A1 2733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.