Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | NAMPT | P43490 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.56 |
| ▸ | GRK2 | P25098 | 3/20 | 0.56 |
| ▸ | PRKCA | P17252 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11078736 | 0.83 | RAB9A (0.74) | RAB9ASMN1; SMN2HPGDNPC1L3MBTL1 | |
| SCHEMBL3462236 | 0.83 | SMN1; SMN2 (0.80) | RAB9ASMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL27952268 | 0.81 | LMNA (0.70) | RAB9ASMN1; SMN2HPGDNPC1L3MBTL1 | |
| SCHEMBL7608096 | 0.80 | ROCK2 (0.50) | RAB9ASMN1; SMN2HPGDNPC1KDR | |
| SCHEMBL1452104 | 0.78 | RAB9A (0.71) | RAB9ASMN1; SMN2NPC1L3MBTL1MEN1 | |
| SCHEMBL3768797 | 0.77 | CYP11B2 (0.61) | SMN1; SMN2NPC1L3MBTL1NAMPTLMNA | |
| SCHEMBL3778572 | 0.76 | PPARG (0.73) | RAB9ASMN1; SMN2HPGDNPC1L3MBTL1 | |
| SCHEMBL7605675 | 0.75 | HTT (0.72) | SMN1; SMN2HPGDL3MBTL1NAMPTKMT2A | |
| SCHEMBL8561634 | 0.75 | EPHX1 (0.60) | SMN1; SMN2NPC1L3MBTL1NAMPTLMNA | |
| SCHEMBL11900328 | 0.74 | HDAC6 (0.87) | RAB9ASMN1; SMN2HPGDNPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7704995-B2 | Protein kinase modulators and methods of use | EXELIXIS, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-20060211709-A1 | Protein kinase modulators and methods of use | EXELIXIS, INC. | 2006-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211709-A1 | Protein kinase modulators and methods of use | GRK2, MAP4K2, MAPKAPK2 | RAB9A 2909/4885SMN1; SMN2 4557/4885HPGD 1272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.