Sugi Predict

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SCHEMBL3461872

SCHEMBL3461872

COC(=O)c1cc(B2OC(C)(C)C(C)(C)O2)ccc1Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 5/20 0.47
▸ KMT2A Q03164 5/20 0.47
▸ ALDH1A1 P00352 4/20 0.47
▸ MAPT P10636 3/20 0.47
▸ HTT P42858 2/20 0.47
▸ NPSR1 Q6W5P4 2/20 0.47
▸ TP53 P04637 1/20 0.47
▸ HPGD P15428 1/20 0.47
▸ MAPK1 P28482 1/20 0.47
▸ HSD17B10 Q99714 1/20 0.47
▸ LMNA P02545 4/20 0.45
▸ SMN1; SMN2 Q16637 2/20 0.45
▸ TSHR P16473 1/20 0.43
▸ AAK1 Q2M2I8 1/20 0.43
▸ HIF1A Q16665 3/20 0.41
▸ DGAT1 O75907 1/20 0.41
▸ KDM4E B2RXH2 1/20 0.40
▸ CA1 P00915 3/20 0.39
▸ CA2 P00918 3/20 0.39
▸ CA9 Q16790 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2792346 0.90 AAK1 (0.44) MEN1KMT2AALDH1A1MAPTHTT
SCHEMBL25035049 0.88 HIF1A (0.43) ALDH1A1MAPTHPGDHSD17B10HIF1A
SCHEMBL27033334 0.85 DGAT1 (0.43) HIF1ADGAT1CA1CA2CA9
SCHEMBL18252711 0.85 CA1 (0.53) LMNATSHRHIF1ADGAT1CA1
SCHEMBL2281668 0.85 ALDH1A1 (0.51) ALDH1A1MAPTHPGDHSD17B10TSHR
SCHEMBL3416598 0.85 HIF1A (0.43) AAK1HIF1ADGAT1CA1CA2
SCHEMBL209359 0.85 HIF1A (0.43) ALDH1A1MAPTHPGDHSD17B10AAK1
SCHEMBL1721722 0.85 ALDH1A1 (0.47) KMT2AALDH1A1MAPTTP53LMNA
SCHEMBL4513021 0.85 CYP4F2 (0.53) KMT2AALDH1A1HPGDMAPK1TSHR
SCHEMBL20448949 0.84 SMN1; SMN2 (0.45) ALDH1A1SMN1; SMN2AAK1HIF1ACA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1837330-A1 Benzamide inhibitors of the P2X7 receptor Pfizer Products Inc. (US) 2007-09-26 — — EP claimed
US-20070142329-A1 Benzamide Inhibitors of the P2X7 Receptor PFIZER INC. 2007-06-21 — — US claimed
EP-3642194-B1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2024-11-27 — — EP disclosed
CN-110770223-B Pesticidally active pyrazole derivatives 先正达参股股份有限公司 2023-08-22 — — CN disclosed
US-11589585-B2 Pesticidally active pyrazole derivatives SYNGENTA PARTICIPATIONS AG (CH) 2023-02-28 — — US disclosed
CN-108463109-B Pesticidally active pyrazole derivatives 先正达参股股份有限公司 2022-04-29 — — CN disclosed
US-20220087262-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2022-03-24 — — US disclosed
US-11071300-B2 Pesticidally active pyrazole derivatives SYNGENTA PARTICIPATIONS AG (CH) 2021-07-27 — — US disclosed
EP-3416959-B1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2021-05-12 — — EP disclosed
US-10874104-B2 Pesticidally active pryazole derivatives SYNGENTA PARTICIPATIONS AG (CH) 2020-12-29 — — US disclosed
US-10750742-B2 Pesticidally active pyrazole derivatives SYNGENTA PARTICIPATIONS AG (CH) 2020-08-25 — — US disclosed
US-7186742-B2 Benzamide inhibitors of the P2X7 receptor PFIZER INC (US) 2007-03-06 — — US disclosed
EP-1626962-B1 BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR PFIZER PROD INC (US) 2007-02-28 — — EP disclosed
EP-1626962-B1 BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR PFIZER PROD INC (US) 2007-02-28 — — EP disclosed
US-20060211709-A1 Protein kinase modulators and methods of use EXELIXIS, INC. 2006-09-21 — — US disclosed
EP-1626962-A1 BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR Pfizer Products Inc. (US) 2006-02-22 — — EP disclosed
EP-1501514-A2 PROTEIN KINASE MODULATORS AND METHODS OF USE Exelixis, Inc. (US) 2005-02-02 — — EP disclosed
US-20050009900-A1 Benzamide inhibitors of the P2X7 receptor ZOETIS LLC 2005-01-13 — — US disclosed
WO-2004099146-A1 BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR PFIZER PRODUCTS INC. (US) 2004-11-18 — — WO disclosed
WO-2003093297-A2 PROTEIN KINASE MODULATORS AND METHODS OF USE EXELIXIS, INC. (US) 2003-11-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060211709-A1 Protein kinase modulators and methods of use GRK2, MAP4K2, MAPKAPK2 MEN1 4800/4885KMT2A 1273/4885ALDH1A1 3298/4885
US-11589585-B2 Pesticidally active pyrazole derivatives CASP3, ACHE, CASP7 MEN1 1985/4885KMT2A 3871/4885ALDH1A1 1505/4885
US-20070142329-A1 Benzamide Inhibitors of the P2X7 Receptor IL1R1, P2RY1, P2RX1 MEN1 2987/4885KMT2A 3644/4885ALDH1A1 365/4885
US-10874104-B2 Pesticidally active pryazole derivatives ACHE, PRXL2A, CASP7 MEN1 3879/4885KMT2A 2460/4885ALDH1A1 252/4885
US-20220087262-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES CASP3, ACHE, CASP7 MEN1 1985/4885KMT2A 3871/4885ALDH1A1 1505/4885
US-10750742-B2 Pesticidally active pyrazole derivatives ACHE, AADAC, CAT MEN1 3921/4885KMT2A 3675/4885ALDH1A1 379/4885
US-20050009900-A1 Benzamide inhibitors of the P2X7 receptor IL1R1, P2RY1, P2RX1 MEN1 2987/4885KMT2A 3644/4885ALDH1A1 365/4885
US-11071300-B2 Pesticidally active pyrazole derivatives ACHE, AADAC, CAT MEN1 3921/4885KMT2A 3675/4885ALDH1A1 379/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.