Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | TTR | P02766 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.38 |
| ▸ | CDC25A | P30304 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4586266 | 0.80 | THRA (0.46) | THRATHRBMAPTCDC25A | |
| SCHEMBL4312066 | 0.79 | THRA (0.52) | THRATHRBALDH1A1AGTR1GAA | |
| SCHEMBL2727920 | 0.79 | FABP4 (0.49) | THRATHRBMAPTCDC25A | |
| SCHEMBL7025179 | 0.79 | KDM4E (0.43) | THRATHRBALDH1A1GAAMAPT | |
| SCHEMBL733998 | 0.78 | EPHX1 (0.55) | ALDH1A1AGTR1GAAMAPTSMN1; SMN2 | |
| SCHEMBL40561 | 0.77 | LMNA (0.45) | THRATHRB | |
| SCHEMBL2728813 | 0.74 | FABP4 (0.56) | ALDH1A1MAPTSMN1; SMN2CYP3A4TSHR | |
| SCHEMBL29894695 | 0.74 | FABP4 (0.56) | ALDH1A1MAPTSMN1; SMN2CYP3A4TSHR | |
| SCHEMBL31028751 | 0.74 | ALDH1A1 (0.70) | ALDH1A1AGTR1GAAMAPTSMN1; SMN2 | |
| SCHEMBL1930556 | 0.73 | SMN1; SMN2 (0.46) | THRATHRBTTRALDH1A1AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035256-A1 | ENDURACIDIN BIOSYNTHETIC GENE CLUSTER FROM STREPTOMYCES FUNGICIDICUS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-02-11 | — | — | US | claimed |
| WO-2008054945-A9 | ENDURACIDIN BIOSYNTHETIC GENE CLUSTER FROM STREPTOMYCES FUNGICIDICUS | OREGON STATE (US) | 2008-08-21 | — | — | WO | claimed |
| WO-2008054945-A2 | ENDURACIDIN BIOSYNTHETIC GENE CLUSTER FROM STREPTOMYCES FUNGICIDICUS | STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON STATE UNIVERSITY (US) | 2008-05-08 | — | — | WO | claimed |
| US-11858967-B2 | Compositions and methods for enhanced production of enduracidin in a genetically engineered strain of streptomyces fungicidicus | OREGON STATE UNIVERSITY (US) | 2024-01-02 | — | — | US | disclosed |
| US-20230120672-A1 | COMPOSITIONS AND METHODS FOR ENHANCED PRODUCTION OF ENDURACIDIN IN A GENETICALLY ENGINEERED STRAIN OF STREPTOMYCES FUNGICIDICUS | UNIV OREGON STATE (US) | 2023-04-20 | — | — | US | disclosed |
| US-11447530-B2 | Compositions and methods for enhanced production of enduracidin in a genetically engineered strain of streptomyces fungicidicus | OREGON STATE UNIVERSITY (US) | 2022-09-20 | — | — | US | disclosed |
| CN-110997700-A | Compositions and methods for enhancing the production of enramycin in genetically engineered strains of streptomyces fungicides | 俄勒冈州立大学 | 2020-04-10 | — | — | CN | disclosed |
| WO-2018106545-A1 | COMPOSITIONS AND METHODS FOR ENHANCED PRODUCTION OF ENDURACIDIN IN A GENETICALLY ENGINEERED STRAIN OF STREPTOMYCES FUNGICIDICUS | OREGON STATE UNIVERSITY (US) | 2018-06-14 | — | — | WO | disclosed |
| WO-2018103905-A1 | MODIFIED STREPTOMYCES FUNGICIDICUS ISOLATES AND THEIR USE | INTERVET INTERNATIONAL B.V. (NL) | 2018-06-14 | — | — | WO | disclosed |
| US-8188245-B2 | Enduracidin biosynthetic gene cluster from streptomyces fungicidicus | STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON STATE UNIVERSITY (US) | 2012-05-29 | — | — | US | disclosed |
| US-20100035256-A1 | ENDURACIDIN BIOSYNTHETIC GENE CLUSTER FROM STREPTOMYCES FUNGICIDICUS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-02-11 | — | — | US | disclosed |
| WO-2008054945-A9 | ENDURACIDIN BIOSYNTHETIC GENE CLUSTER FROM STREPTOMYCES FUNGICIDICUS | OREGON STATE (US) | 2008-08-21 | — | — | WO | disclosed |
| WO-2008054945-A2 | ENDURACIDIN BIOSYNTHETIC GENE CLUSTER FROM STREPTOMYCES FUNGICIDICUS | STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON STATE UNIVERSITY (US) | 2008-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035256-A1 | ENDURACIDIN BIOSYNTHETIC GENE CLUSTER FROM STREPTOMYCES FUNGICIDICUS | RNGTT, ETF1, ODC1 | THRA 4322/4885THRB 4324/4885TTR 4745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.