Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 1/20 | 0.57 |
| ▸ | MIF | P14174 | 3/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | NAAA | Q02083 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1523403 | 0.93 | MIF (0.57) | HTR3AMIFHDAC3HDAC4HDAC1 | |
| SCHEMBL29152182 | 0.91 | NAAA (0.58) | HTR3AMIFHDAC1HDAC2SIGMAR1 | |
| SCHEMBL21694457 | 0.91 | MIF (0.55) | HTR3AMIFHDAC3HDAC4HDAC1 | |
| SCHEMBL5035695 | 0.91 | MIF (0.55) | HTR3AMIFHDAC3HDAC4HDAC1 | |
| SCHEMBL10456657 | 0.91 | MIF (0.55) | HTR3AMIFHDAC3HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL28503124 | 0.91 | MIF (0.55) | HTR3AMIFHDAC3HDAC4HDAC1 | |
| SCHEMBL20195110 | 0.87 | FFAR1 (0.50) | HTR3AMIFHDAC1HDAC2 | |
| SCHEMBL944031 | 0.85 | HIF1A (0.52) | HTR3AMIFHDAC3HDAC4HDAC1 | |
| P-Xylene SCHEMBL28772421 | 0.84 | SCN5A (0.52) | MIFSIGMAR1MAOANAAAMAPT | |
| Toluene SCHEMBL27574812 | 0.84 | SCN5A (0.49) | HTR3AMIFSIGMAR1MAOANAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100240602-A1 | METHODS AND COMPOSITIONS FOR OPTIMIZING BLOOD AND TISSUE STABILITY OF CAMPTOTHECIN AND OTHER ALBUMIN-BINDING THERAPEUTIC COMPOUNDS | BURKE THOMAS G | 2010-09-23 | — | — | US | claimed |
| EP-1372571-A4 | METHOD AND COMPOSITIONS FOR OPTIMIZING BLOOD AND TISSUE STABILITY OF CAMPTOTHECIN AND OTHER ALBUMIN-BINDING THERAPEUTIC COMPOUNDS | NEW CENTURY PHARMACEUTICALS (US) | 2006-06-07 | — | — | EP | claimed |
| EP-1372571-A2 | METHOD AND COMPOSITIONS FOR OPTIMIZING BLOOD AND TISSUE STABILITY OF CAMPTOTHECIN AND OTHER ALBUMIN-BINDING THERAPEUTIC COMPOUNDS | New Century Pharmaceuticals, Inc. (US) | 2004-01-02 | — | — | EP | claimed |
| US-20020193318-A1 | Methods and compositions for optimizing blood and tissue stability of camptothecin and other albumin-binding therapeutic compounds | NEW CENTURY PHARMACEUTICALS, INC. | 2002-12-19 | — | — | US | claimed |
| WO-2002074246-A2 | METHOD AND COMPOSITIONS FOR OPTIMIZING BLOOD AND TISSUE STABILITY OF CAMPTOTHECIN AND OTHER ALBUMIN-BINDING THERAPEUTIC COMPOUNDS | NEW CENTURY PHARMACEUTICALS, INC. (US) | 2002-09-26 | — | — | WO | claimed |
| EP-3443959-A1 | SULFAMATE DERIVATIVE COMPOUNDS FOR USE IN TREATING OR ALLEVIATING PAIN | Bio-Pharm Solutions Co., Ltd. (KR) | 2019-02-20 | — | — | EP | disclosed |
| US-10201617-B2 | 3-substituted piperidine-2, 6-diones and non-covalent complexes with albumin | ZHUHAI BEIHAI BIOTECH CO., LTD. (CN) | 2019-02-12 | — | — | US | disclosed |
| US-9962452-B2 | Soluble complexes of drug analogs and albumin | ZHUHAI BEIHAI BIOTECH CO., LTD. (CN) | 2018-05-08 | — | — | US | disclosed |
| US-9937259-B2 | Abiraterone derivatives and non-covalent complexes with albumin | ZHUHAI BEIHAI BIOTECH CO., LTD. (CN) | 2018-04-10 | — | — | US | disclosed |
| US-20170319708-A1 | 3-Substituted Piperidine-2, 6-Diones and Non-Covalent Complexes with Albumin | ZHUHAI BEIHAI BIOTECH CO., LTD. (CN) | 2017-11-09 | — | — | US | disclosed |
| US-20170216443-A1 | ABIRATERONE DERIVATIVES AND NON-COVALENT COMPLEXES WITH ALBUMIN | ZHUHAI BEIHAI BIOTECH CO., LTD. (CN) | 2017-08-03 | — | — | US | disclosed |
| WO-2016005407-A1 | ONE-POT SYNTHESIS OF SQUARAMIDES | UNIVERSIDAD DE ZARAGOZA (ES) | 2016-01-14 | — | — | WO | disclosed |
| WO-2012156367-A1 | AMINO-SUBSTITUTED IMIDAZOPYRIDAZINES AS MKNK1 KINASE INHIBITORS | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-11-22 | — | — | WO | disclosed |
| US-20100256383-A1 | Compounds and Methods of Arylmethylation (Benzylation) As Protection For Alcohol Groups During Chemical Synthesis | DUDLEY GREGORY | 2010-10-07 | — | — | US | disclosed |
| US-20100240602-A1 | METHODS AND COMPOSITIONS FOR OPTIMIZING BLOOD AND TISSUE STABILITY OF CAMPTOTHECIN AND OTHER ALBUMIN-BINDING THERAPEUTIC COMPOUNDS | BURKE THOMAS G | 2010-09-23 | — | — | US | disclosed |
| US-7691872-B2 | Methods and compositions for optimizing blood and tissue stability of camptothecin and other albumin-binding therapeutic compounds | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2010-04-06 | — | — | US | disclosed |
| EP-1372571-A4 | METHOD AND COMPOSITIONS FOR OPTIMIZING BLOOD AND TISSUE STABILITY OF CAMPTOTHECIN AND OTHER ALBUMIN-BINDING THERAPEUTIC COMPOUNDS | NEW CENTURY PHARMACEUTICALS (US) | 2006-06-07 | — | — | EP | disclosed |
| EP-1372571-A2 | METHOD AND COMPOSITIONS FOR OPTIMIZING BLOOD AND TISSUE STABILITY OF CAMPTOTHECIN AND OTHER ALBUMIN-BINDING THERAPEUTIC COMPOUNDS | New Century Pharmaceuticals, Inc. (US) | 2004-01-02 | — | — | EP | disclosed |
| US-20020193318-A1 | Methods and compositions for optimizing blood and tissue stability of camptothecin and other albumin-binding therapeutic compounds | NEW CENTURY PHARMACEUTICALS, INC. | 2002-12-19 | — | — | US | disclosed |
| WO-2002074246-A2 | METHOD AND COMPOSITIONS FOR OPTIMIZING BLOOD AND TISSUE STABILITY OF CAMPTOTHECIN AND OTHER ALBUMIN-BINDING THERAPEUTIC COMPOUNDS | NEW CENTURY PHARMACEUTICALS, INC. (US) | 2002-09-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170216443-A1 | ABIRATERONE DERIVATIVES AND NON-COVALENT COMPLEXES WITH ALBUMIN | CYP17A1, SHBG, CYP19A1 | HTR3A 3912/4885MIF 3978/4885HDAC3 3051/4885 |
| US-10201617-B2 | 3-substituted piperidine-2, 6-diones and non-covalent complexes with albumin | ALB, BCL9, CD2BP2 | HTR3A 3878/4885MIF 3996/4885HDAC3 1911/4885 |
| US-20170319708-A1 | 3-Substituted Piperidine-2, 6-Diones and Non-Covalent Complexes with Albumin | ALB, BCL9, CD2BP2 | HTR3A 3878/4885MIF 3996/4885HDAC3 1911/4885 |
| US-20100240602-A1 | METHODS AND COMPOSITIONS FOR OPTIMIZING BLOOD AND TISSUE STABILITY OF CAMPTOTHECIN AND OTHER ALBUMIN-BINDING THERAPEUTIC COMPOUNDS | ALB, MTHFD1, DHFR | HTR3A 3880/4885MIF 65/4885HDAC3 3856/4885 |
| US-20020193318-A1 | Methods and compositions for optimizing blood and tissue stability of camptothecin and other albumin-binding therapeutic compounds | ALB, TYMP, SHBG | HTR3A 2461/4885MIF 396/4885HDAC3 4597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.