Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.52 |
| ▸ | CCR5 | P51681 | 1/20 | 0.52 |
| ▸ | CCR8 | P51685 | 1/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 11/20 | 0.51 |
| ▸ | NOS3 | P29474 | 2/20 | 0.48 |
| ▸ | NOS1 | P29475 | 2/20 | 0.48 |
| ▸ | NOS2 | P35228 | 2/20 | 0.48 |
| ▸ | PLAU | P00749 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5700016 | 0.83 | CCR1 (0.53) | CCR1CCR5CCR8NFE2L2NOS3 | |
| SCHEMBL1827524 | 0.81 | NFE2L2 (0.57) | CCR1CCR5CCR8NFE2L2NOS3 | |
| SCHEMBL30646282 | 0.81 | NOS3 (0.53) | CCR1CCR5CCR8NFE2L2NOS3 | |
| SCHEMBL27326954 | 0.80 | NFE2L2 (0.50) | CCR1CCR5CCR8NFE2L2NOS3 | |
| SCHEMBL8434248 | 0.75 | UHRF1 (0.46) | CCR1CCR5CCR8NOS3NOS1 | |
| SCHEMBL3467794 | 0.74 | FFAR1 (0.36) | CCR1CCR5CCR8NFE2L2NOS3 | |
| Fluoride SCHEMBL27839384 | 0.73 | UHRF1 (0.45) | CCR1CCR5CCR8NOS3NOS1 | |
| SCHEMBL7870068 | 0.72 | LMNA (0.38) | LMNAKDM4E | |
| SCHEMBL8847160 | 0.72 | ALDH1A1 (0.41) | CCR1CCR5CCR8LMNAKDM4E | |
| SCHEMBL3468851 | 0.72 | NFE2L2 (0.48) | NFE2L2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010085968-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE AS HIF-INHIBITORS | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2010-08-05 | — | — | WO | disclosed |
| WO-2010076034-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE AS-INHIBITORS | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2010-07-08 | — | — | WO | disclosed |