Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.40 |
| ▸ | APLNR | P35414 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27809965 | 0.98 | NAMPT (0.42) | NAMPTMKNK2ROCK2MAP4K4PRKACA | |
| SCHEMBL18247262 | 0.82 | APLNR (0.55) | MKNK2ROCK2MAP4K4PRKACAROCK1 | |
| SCHEMBL2201631 | 0.82 | PTGS2 (0.44) | NAMPTMKNK2ROCK2MAP4K4PRKACA | |
| SCHEMBL3215669 | 0.81 | NFE2L2 (0.40) | NAMPTMKNK2ROCK2MAP4K4PRKACA | |
| SCHEMBL5082291 | 0.79 | NAPRT (0.54) | NAPRTAPLNRCYP2C9 | |
| SCHEMBL29097768 | 0.79 | TRPA1 (0.39) | MKNK2ROCK2MAP4K4PRKACAROCK1 | |
| SCHEMBL30198665 | 0.79 | TRPA1 (0.39) | MKNK2ROCK2MAP4K4PRKACAROCK1 | |
| SCHEMBL669049 | 0.77 | ALDH1A1 (0.52) | CYP1A1CYP1B1GAA | |
| Hydrochloric Acid SCHEMBL11156696 | 0.75 | ALDH1A1 (0.50) | CYP1A1CYP1B1GAA | |
| SCHEMBL28943258 | 0.75 | ALDH1A1 (0.50) | CYP1A1CYP1B1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010085968-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE AS HIF-INHIBITORS | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2010-08-05 | — | — | WO | disclosed |
| WO-2010076034-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE AS-INHIBITORS | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2010-07-08 | — | — | WO | disclosed |