Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.60 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.52 |
| ▸ | CCR6 | P51684 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1093569 | 0.87 | GLO1 (0.55) | POLBHSD11B1SCN9AKDM4ESLC22A12 | |
| SCHEMBL21275485 | 0.85 | KDM4E (0.59) | HSD11B1SCN9AKDM4ESLC22A12CCR6 | |
| SCHEMBL24697645 | 0.81 | SCN9A (0.55) | POLBHSD11B1SCN9AKDM4ESLC22A12 | |
| SCHEMBL3475805 | 0.81 | SCN9A (0.56) | POLBHSD11B1SCN9AKDM4ESLC22A12 | |
| SCHEMBL16897001 | 0.79 | HSD11B1 (0.60) | POLBHSD11B1SCN9AKDM4ESLC22A12 | |
| SCHEMBL12017952 | 0.78 | SLC22A12 (0.48) | HSD11B1SCN9AKDM4ESLC22A12CCR6 | |
| SCHEMBL16177989 | 0.76 | ALDH1A1 (0.72) | POLBKDM4EALDH1A1PKMGAA | |
| SCHEMBL29151336 | 0.76 | POLB (0.67) | POLBKDM4EALDH1A1PKMGAA | |
| SCHEMBL29023902 | 0.76 | POLB (1.00) | POLBKDM4EALDH1A1PKMGAA | |
| SCHEMBL29967697 | 0.76 | ALDH1A1 (0.72) | POLBKDM4EALDH1A1PKMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8907101-B2 | Sulfonamide derivatives | PFIZER LIMITED (GB) | 2014-12-09 | — | — | US | disclosed |
| US-20130338111-A1 | Sulfonamide Derivatives | ICAGEN, INC. (US) | 2013-12-19 | — | — | US | disclosed |
| US-20120149679-A1 | Sulfonamide Derivatives | ICAGEN, INC. | 2012-06-14 | — | — | US | disclosed |
| US-20100197655-A1 | SULFONAMIDE DERIVATIVES | Pfizer Limited Icagen, Inc. | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197655-A1 | SULFONAMIDE DERIVATIVES | SULT2A1, SULT1A1, TPST2 | POLB 3499/4885HSD11B1 817/4885SCN9A 73/4885 |
| US-20130338111-A1 | Sulfonamide Derivatives | SULT2A1, SULT1A1, TPST2 | POLB 3499/4885HSD11B1 817/4885SCN9A 73/4885 |
| US-20120149679-A1 | Sulfonamide Derivatives | SULT2A1, SULT1A1, TPST2 | POLB 3499/4885HSD11B1 817/4885SCN9A 73/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.