Sugi Predict

Sugi Predict / Compounds / SCHEMBL3480329

SCHEMBL3480329

SCHEMBL3480329

O=C(Nc1ccc2sc(S(=O)(=O)NCP(=O)(O)O)cc2c1)c1ccc(O)c(O)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TOP1 P11387 4/20 0.47
▸ HDAC1 Q13547 2/20 0.40
▸ SNCA P37840 2/20 0.40
▸ ALOX15 P16050 2/20 0.37
▸ MEN1 O00255 2/20 0.37
▸ KMT2A Q03164 2/20 0.37
▸ MAPT P10636 2/20 0.37
▸ LMNA P02545 1/20 0.37
▸ MAPK1 P28482 1/20 0.37
▸ TERT O14746 1/20 0.37
▸ NSD2 O96028 1/20 0.37
▸ POLB P06746 1/20 0.37
▸ GAA P10253 1/20 0.37
▸ GFER P55789 1/20 0.37
▸ TRPV1 Q8NER1 2/20 0.37
▸ CA2 P00918 2/20 0.36
▸ CASP6 P55212 1/20 0.35
▸ CTDSP1 Q9GZU7 1/20 0.35
▸ PDGFRB P09619 2/20 0.35
▸ KDR P35968 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3480605 0.87 TOP1 (0.35) TOP1MAPTLMNAPOLBGAA
SCHEMBL3483648 0.85 CA1 (0.36) TOP1HDAC1MEN1KMT2AMAPT
SCHEMBL3480060 0.82 TERT (0.49) HDAC1ALOX15MEN1KMT2ALMNA
SCHEMBL3483343 0.81 HDAC1 (0.40) HDAC1MEN1KMT2AMAPTLMNA
SCHEMBL14931228 0.81 CA2 (0.46) HDAC1TERTCA2
SCHEMBL3483512 0.80 BCL9 (0.38) HDAC1MEN1KMT2AMAPTLMNA
SCHEMBL13024348 0.80 KCNQ3 (0.39) TOP1MEN1KMT2AMAPTLMNA
SCHEMBL13021962 0.78 PLA2G7 (0.37) PDGFRBKDR
SCHEMBL3484113 0.78 HDAC1 (0.36) HDAC1MEN1KMT2AMAPTLMNA
SCHEMBL3480294 0.78 XDH (0.35) TOP1MEN1KMT2AMAPK1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100317625-A1 NOVEL SULFONAMIDOMETHYLPHOSPHONATE INHIBITORS OF BETA-LACTAMASE 92229129 QUEBEC INC. (CA) 2010-12-16 — — US claimed
EP-2024376-A1 NOVEL SULFONAMIDOMETHYLPHOSPHONATE INHIBITORS OF BETA-LACTAMASE Merck & Co., Inc. (US) 2009-02-18 — — EP claimed
WO-2007139729-A1 NOVEL SULFONAMIDOMETHYLPHOSPHONATE INHIBITORS OF BETA-LACTAMASE MERCK & CO., INC. (US) 2007-12-06 — — WO claimed
US-20100317625-A1 NOVEL SULFONAMIDOMETHYLPHOSPHONATE INHIBITORS OF BETA-LACTAMASE 92229129 QUEBEC INC. (CA) 2010-12-16 — — US disclosed
EP-2024376-A1 NOVEL SULFONAMIDOMETHYLPHOSPHONATE INHIBITORS OF BETA-LACTAMASE Merck & Co., Inc. (US) 2009-02-18 — — EP disclosed
WO-2007139729-A1 NOVEL SULFONAMIDOMETHYLPHOSPHONATE INHIBITORS OF BETA-LACTAMASE MERCK & CO., INC. (US) 2007-12-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100317625-A1 NOVEL SULFONAMIDOMETHYLPHOSPHONATE INHIBITORS OF BETA-LACTAMASE MGAM, BPGM, PPME1 TOP1 828/4885HDAC1 2218/4885SNCA 2555/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.