SCHEMBL3482596

SCHEMBL3482596

Cc1ccc(N2[CH]CNCC2)cc1C

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB1 P08588 3/20 0.59
HTR7 P34969 2/20 0.42
ALDH1A1 P00352 5/20 0.36
HPGD P15428 1/20 0.36
CYP3A4 P08684 3/20 0.35
CYP1A2 P05177 2/20 0.35
HTR1A P08908 2/20 0.35
CYP2D6 P10635 2/20 0.35
CYP2C9 P11712 2/20 0.35
HTR3A P46098 2/20 0.35
GAA P10253 4/20 0.34
MAPT P10636 4/20 0.34
KMT2A Q03164 2/20 0.34
KDM4E B2RXH2 1/20 0.34
MEN1 O00255 1/20 0.34
LMNA P02545 1/20 0.34
NOTUM Q6P988 1/20 0.33
TSHR P16473 1/20 0.33
CYP2C19 P33261 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6645954 0.80 ADRB1 (0.55) ADRB1HTR7ALDH1A1CYP3A4CYP1A2
SCHEMBL3482360 0.76 ADRB1 (0.59) ADRB1ALDH1A1HTR3AGAAMAPT
SCHEMBL221254 0.74 ADRB1 (1.00) ADRB1HTR7CYP3A4CYP1A2HTR1A
SCHEMBL6094315 0.73 QDPR (0.39) ADRB1ALDH1A1HTR3AGAAMAPT
SCHEMBL3483001 0.73 ADRB1 (0.55) ADRB1HTR7CYP3A4CYP1A2HTR1A
SCHEMBL4094720 0.73 HTR7 (0.39) ADRB1HTR7ALDH1A1HTR1AHTR3A
SCHEMBL2410875 0.72 ADRB1 (0.59) ADRB1HTR7HTR1AHTR3A
SCHEMBL3482603 0.72 ADRB1 (0.62) ADRB1HTR7HTR1AHTR3AMAPT
SCHEMBL739058 0.72 SIGMAR1 (0.52) ADRB1HTR7ALDH1A1CYP3A4CYP1A2
SCHEMBL4885913 0.71 HTR2C (0.60) ADRB1HTR7ALDH1A1CYP3A4CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2150550-A1 NOVEL CARBAMOYLOXY ARYL ALKAN ARYLPIPERAZINE COMPOUND, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUND AND METHOD FOR TREATING PAIN, ANXIETY AND DEPRESSION BY ADMINISTERING THE COMPOUND SK Holdings Co., Ltd. (KR) 2010-02-10 EP disclosed
WO-2008140197-A1 NOVEL CARBAMOYLOXY ARYL ALKAN ARYLPIPERAZINE COMPOUND, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUND AND METHOD FOR TREATING PAIN, ANXIETY AND DEPRESSION BY ADMINISTERING THE COMPOUND SK HOLDINGS CO., LTD. (KR) 2008-11-20 WO disclosed