SCHEMBL3482923

SCHEMBL3482923

COc1ccccc1N1CCN(C(CCOC(N)=O)c2ccc(F)cc2)CC1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 2/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
MAPT P10636 1/20 0.50
THRB P10828 1/20 0.50
GAA P10253 1/20 0.48
ALDH1A1 P00352 3/20 0.48
POLB P06746 1/20 0.48
MAPK1 P28482 1/20 0.47
MEN1 O00255 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2C19 P33261 1/20 0.47
KMT2A Q03164 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
TSHR P16473 2/20 0.47
HTR1A P08908 1/20 0.47
DRD2 P14416 1/20 0.47
ADRB2 P07550 1/20 0.46
ADRB1 P08588 1/20 0.46
ADRB3 P13945 1/20 0.46
ADRA1D P25100 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3482665 0.91 LMNA (0.50) TP53L3MBTL1MAPTGAAALDH1A1
SCHEMBL3483116 0.90 MEN1 (0.50) L3MBTL1MAPTGAAALDH1A1POLB
SCHEMBL3482959 0.89 AOC3 (0.43) TP53MAPTTHRBADRB2ADRB1
SCHEMBL3482318 0.88 CYP2C9 (0.42) TP53MAPTTHRBPOLBMAPK1
SCHEMBL3483021 0.82 MC4R (0.46) TP53MAPTGAAALDH1A1POLB
SCHEMBL3482900 0.82 KMT2A (0.52) TP53L3MBTL1MAPTPOLBMEN1
SCHEMBL3482581 0.79 ME2 (0.46) TP53MAPTGAAALDH1A1MEN1
SCHEMBL2117976 0.76 ADRB1 (0.60) ALDH1A1POLBHTR1ADRD2ADRB1
SCHEMBL28729033 0.76 KDM4E (0.65) ALDH1A1MEN1KMT2AHTR1ADRD2
SCHEMBL3482997 0.75 POLB (0.54) TP53MAPTALDH1A1POLBMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2150550-A1 NOVEL CARBAMOYLOXY ARYL ALKAN ARYLPIPERAZINE COMPOUND, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUND AND METHOD FOR TREATING PAIN, ANXIETY AND DEPRESSION BY ADMINISTERING THE COMPOUND SK Holdings Co., Ltd. (KR) 2010-02-10 EP disclosed
WO-2008140197-A1 NOVEL CARBAMOYLOXY ARYL ALKAN ARYLPIPERAZINE COMPOUND, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUND AND METHOD FOR TREATING PAIN, ANXIETY AND DEPRESSION BY ADMINISTERING THE COMPOUND SK HOLDINGS CO., LTD. (KR) 2008-11-20 WO disclosed