Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 13/20 | 0.70 |
| ▸ | MEN1 | O00255 | 12/20 | 0.70 |
| ▸ | RAB9A | P51151 | 11/20 | 0.70 |
| ▸ | NPC1 | O15118 | 9/20 | 0.70 |
| ▸ | MAPT | P10636 | 8/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.70 |
| ▸ | HPGD | P15428 | 4/20 | 0.70 |
| ▸ | GAA | P10253 | 4/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | CASP3 | P42574 | 3/20 | 0.69 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.69 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.69 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.67 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.67 |
| ▸ | RELA | Q04206 | 3/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3484048 | 0.93 | MEN1 (0.81) | KMT2AMEN1RAB9ANPC1MAPT | |
| SCHEMBL29858589 | 0.92 | KMT2A (0.80) | KMT2AMEN1RAB9ANPC1MAPT | |
| SCHEMBL3429429 | 0.92 | KMT2A (0.80) | KMT2AMEN1RAB9ANPC1MAPT | |
| SCHEMBL10357565 | 0.90 | MEN1 (0.72) | KMT2AMEN1RAB9ANPC1MAPT | |
| SCHEMBL10357534 | 0.89 | KMT2A (0.80) | KMT2AMEN1RAB9ANPC1MAPT | |
| SCHEMBL1608474 | 0.88 | RAB9A (0.58) | KMT2AMEN1RAB9ANPC1MAPT | |
| SCHEMBL14758271 | 0.88 | MEN1 (0.87) | KMT2AMEN1RAB9ANPC1MAPT | |
| SCHEMBL10358277 | 0.83 | MEN1 (0.83) | KMT2AMEN1RAB9ANPC1MAPT | |
| SCHEMBL1181434 | 0.82 | RAB9A (1.00) | KMT2AMEN1RAB9ANPC1MAPT | |
| SCHEMBL10357520 | 0.82 | KMT2A (0.83) | KMT2AMEN1RAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9867879-B2 | Methods for use of small molecule activators of hem-Y / protoporphyrinogen oxidase (PPO) | VANDERBILT UNIVERSITY (US) | 2018-01-16 | — | — | US | disclosed |
| US-20170246149-A1 | COMPOSITIONS AND METHODS FOR TREATING MICROBIAL INFECTIONS | VANDERBILT UNIVERSITY | 2017-08-31 | — | — | US | disclosed |
| US-20170246149-A1 | COMPOSITIONS AND METHODS FOR TREATING MICROBIAL INFECTIONS | VANDERBILT UNIVERSITY | 2017-08-31 | — | — | US | disclosed |
| US-20160213780-A1 | METHODS FOR USE OF SMALL MOLECULE ACTIVATORS OF HEM-Y / PROTOPORPHYRINOGEN OXIDASE (PPO) | VANDERBILT UNIVERSITY | 2016-07-28 | — | — | US | disclosed |
| US-20150174130-A1 | COMPOSITIONS AND METHODS FOR TREATING MICROBIAL INFECTIONS | VANDERBILT UNIVERSITY | 2015-06-25 | — | — | US | disclosed |
| US-20150174130-A1 | COMPOSITIONS AND METHODS FOR TREATING MICROBIAL INFECTIONS | VANDERBILT UNIVERSITY | 2015-06-25 | — | — | US | disclosed |
| US-8263642-B2 | Antimicrobial compounds and methods of use thereof | VANDERBILT UNIVERSITY (US) | 2012-09-11 | — | — | US | disclosed |
| US-8263642-B2 | Antimicrobial compounds and methods of use thereof | VANDERBILT UNIVERSITY (US) | 2012-09-11 | — | — | US | disclosed |
| US-8263642-B2 | Antimicrobial compounds and methods of use thereof | VANDERBILT UNIVERSITY (US) | 2012-09-11 | — | — | US | disclosed |
| US-20100004324-A1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF USE THEREOF | VANDERBILT UNIVERSITY | 2010-01-07 | — | — | US | disclosed |
| US-20100004324-A1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF USE THEREOF | VANDERBILT UNIVERSITY | 2010-01-07 | — | — | US | disclosed |
| US-20100004324-A1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF USE THEREOF | VANDERBILT UNIVERSITY | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004324-A1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF USE THEREOF | HMOX1, HMOX2, NOD2 | KMT2A 4544/4885MEN1 4247/4885RAB9A 3460/4885 |
| US-20160213780-A1 | METHODS FOR USE OF SMALL MOLECULE ACTIVATORS OF HEM-Y / PROTOPORPHYRINOGEN OXIDASE (PPO) | PPOX, HCCS, HMOX2 | KMT2A 1359/4885MEN1 4876/4885RAB9A 1246/4885 |
| US-20150174130-A1 | COMPOSITIONS AND METHODS FOR TREATING MICROBIAL INFECTIONS | HMOX1, HMOX2, HMBS | KMT2A 4163/4885MEN1 4846/4885RAB9A 1155/4885 |
| US-20170246149-A1 | COMPOSITIONS AND METHODS FOR TREATING MICROBIAL INFECTIONS | HMOX1, HMOX2, HMBS | KMT2A 4163/4885MEN1 4846/4885RAB9A 1155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.