Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 13/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 8/20 | 0.38 |
| ▸ | PGR | P06401 | 3/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3485497 | 0.84 | NR3C2 (0.38) | NR3C2NR3C1PGRCYP19A1CHRM5 | |
| SCHEMBL1270432 | 0.75 | ALDH1A1 (0.45) | — | |
| SCHEMBL3484893 | 0.74 | KCNQ2 (0.38) | NR3C2NR3C1PGRCHRM5CHRM1 | |
| SCHEMBL25883473 | 0.65 | NR3C1 (0.45) | NR3C2NR3C1PGRCYP19A1CHRM5 | |
| SCHEMBL19418286 | 0.64 | NR3C2 (0.44) | NR3C2NR3C1PGRDRD2 | |
| SCHEMBL17169807 | 0.64 | RIPK1 (0.40) | NR3C2NR3C1PGRNPY5R | |
| SCHEMBL12345879 | 0.64 | XIAP (0.45) | — | |
| Hydrochloric Acid SCHEMBL2235022 | 0.63 | XIAP (0.44) | — | |
| SCHEMBL9029862 | 0.63 | NR3C2 (0.56) | NR3C2NR3C1PGR | |
| SCHEMBL9029850 | 0.63 | NR3C2 (0.56) | NR3C2NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144715-A1 | Substituted Benzodiazepinones, Benzoxazepinones and Benzothiazepinones as Sodium Channel Blockers | MERCK SHARP & DOHME CORP. | 2010-06-10 | — | — | US | disclosed |
| US-20100144715-A1 | Substituted Benzodiazepinones, Benzoxazepinones and Benzothiazepinones as Sodium Channel Blockers | MERCK SHARP & DOHME CORP. | 2010-06-10 | — | — | US | disclosed |
| US-20100144715-A1 | Substituted Benzodiazepinones, Benzoxazepinones and Benzothiazepinones as Sodium Channel Blockers | MERCK SHARP & DOHME CORP. | 2010-06-10 | — | — | US | disclosed |
| EP-2131657-A1 | SUBSTITUTED BENZODIAZEPINONES, BENZOXAZEPINONES AND BENZOTHIAZEPINONES AS SODIUM CHANNEL BLOCKERS | Merck & Co., Inc. (US) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106077-A1 | SUBSTITUTED BENZODIAZEPINONES, BENZOXAZEPINONES AND BENZOTHIAZEPINONES AS SODIUM CHANNEL BLOCKERS | MERCK & CO., INC. (US) | 2008-09-04 | — | — | WO | disclosed |
| WO-2008106077-A1 | SUBSTITUTED BENZODIAZEPINONES, BENZOXAZEPINONES AND BENZOTHIAZEPINONES AS SODIUM CHANNEL BLOCKERS | MERCK & CO., INC. (US) | 2008-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144715-A1 | Substituted Benzodiazepinones, Benzoxazepinones and Benzothiazepinones as Sodium Channel Blockers | TRPV1, TRPV4, CACNA1B | NR3C2 385/4885NR3C1 581/4885PGR 2389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.