Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3956783 | 0.78 | ALDH1A1 (0.53) | TSHRCA2ALOX15ALDH1A1TDP1 | |
| SCHEMBL1128730 | 0.77 | P4HB (0.42) | TSHRCA2ALOX15ALDH1A1TDP1 | |
| SCHEMBL3883261 | 0.76 | FBP1 (0.42) | TSHRCA2ALDH1A1MAPTTXN | |
| SCHEMBL29722954 | 0.76 | FBP1 (0.42) | TSHRCA2ALDH1A1MAPTTXN | |
| SCHEMBL10664438 | 0.75 | TYR (0.42) | TSHRCA2ALOX15TDP1CA12 | |
| SCHEMBL19440433 | 0.75 | ALDH1A1 (0.43) | TSHRCA2ALOX15ALDH1A1TDP1 | |
| SCHEMBL29723323 | 0.74 | TXN (0.37) | ALDH1A1NPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL1648559 | 0.74 | HTR7 (0.44) | TSHRCA2ALDH1A1LMNAMAPT | |
| SCHEMBL4268182 | 0.74 | FBP1 (0.37) | MAPTTXNFBP1APOBEC3G | |
| SCHEMBL16326729 | 0.74 | APOBEC3G (0.45) | MAPTL3MBTL1TXNFBP1APOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010556-A4 | HOMOGENEOUS ERYTHROPOIETIN AND OTHER PEPTIDES AND PROTEINS, METHODS AND INTERMEDIATES FOR THEIR PREPARATION | SLOAN KETTERING INST CANCER (US) | 2009-09-02 | — | — | EP | claimed |
| EP-2010556-A2 | HOMOGENEOUS ERYTHROPOIETIN AND OTHER PEPTIDES AND PROTEINS, METHODS AND INTERMEDIATES FOR THEIR PREPARATION | Sloan-Kettering Institute for Cancer Research (US) | 2009-01-07 | — | — | EP | claimed |
| WO-2007120614-A2 | HOMOGENEOUS ERYTHROPOIETIN AND OTHER PEPTIDES AND PROTEINS, METHODS AND INTERMEDIATES FOR THEIR PREPARATION | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2007-10-25 | — | — | WO | claimed |
| EP-2010556-B1 | HOMOGENEOUS ERYTHROPOIETIN AND METHOD FOR THEIR PREPARATION | SLOAN KETTERING INST CANCER (US) | 2015-09-23 | — | — | EP | disclosed |
| EP-2010556-B1 | HOMOGENEOUS ERYTHROPOIETIN AND METHOD FOR THEIR PREPARATION | SLOAN KETTERING INST CANCER (US) | 2015-09-23 | — | — | EP | disclosed |
| US-8754192-B2 | Compositions comprising homogeneously glycosylated erythropoietin | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2014-06-17 | — | — | US | disclosed |
| US-8754192-B2 | Compositions comprising homogeneously glycosylated erythropoietin | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2014-06-17 | — | — | US | disclosed |
| US-20100081786-A1 | Homogeneous Erythropoietin and Other Peptides and Proteins, Methods and Intermediates for Their Preparation | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-01 | — | — | US | disclosed |
| US-20100081786-A1 | Homogeneous Erythropoietin and Other Peptides and Proteins, Methods and Intermediates for Their Preparation | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-01 | — | — | US | disclosed |
| US-20100081786-A1 | Homogeneous Erythropoietin and Other Peptides and Proteins, Methods and Intermediates for Their Preparation | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-01 | — | — | US | disclosed |
| US-7635750-B2 | Reacting a peptide acyl donor comprising a peptidic backbone made up of two or more amino acids with a peptide amine acceptor under reducing reaction conditions employing an excess of a reducing agent; | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2009-12-22 | — | — | US | disclosed |
| US-7635750-B2 | Reacting a peptide acyl donor comprising a peptidic backbone made up of two or more amino acids with a peptide amine acceptor under reducing reaction conditions employing an excess of a reducing agent; | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2009-12-22 | — | — | US | disclosed |
| EP-2010556-A4 | HOMOGENEOUS ERYTHROPOIETIN AND OTHER PEPTIDES AND PROTEINS, METHODS AND INTERMEDIATES FOR THEIR PREPARATION | SLOAN KETTERING INST CANCER (US) | 2009-09-02 | — | — | EP | disclosed |
| EP-2010556-A2 | HOMOGENEOUS ERYTHROPOIETIN AND OTHER PEPTIDES AND PROTEINS, METHODS AND INTERMEDIATES FOR THEIR PREPARATION | Sloan-Kettering Institute for Cancer Research (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007120614-A2 | HOMOGENEOUS ERYTHROPOIETIN AND OTHER PEPTIDES AND PROTEINS, METHODS AND INTERMEDIATES FOR THEIR PREPARATION | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2007-10-25 | — | — | WO | disclosed |
| WO-2007120614-A2 | HOMOGENEOUS ERYTHROPOIETIN AND OTHER PEPTIDES AND PROTEINS, METHODS AND INTERMEDIATES FOR THEIR PREPARATION | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2007-10-25 | — | — | WO | disclosed |
| US-20070173636-A1 | Method for preparing polyfunctionalized peptides and/or proteins via native chemical ligation | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-07-26 | — | — | US | disclosed |
| US-20070173636-A1 | Method for preparing polyfunctionalized peptides and/or proteins via native chemical ligation | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100081786-A1 | Homogeneous Erythropoietin and Other Peptides and Proteins, Methods and Intermediates for Their Preparation | EPOR, LIFR, LNPEP | TSHR 1121/4885CA2 3854/4885ALOX15 2235/4885 |
| US-20070173636-A1 | Method for preparing polyfunctionalized peptides and/or proteins via native chemical ligation | TXNL1, NGLY1, RXFP1 | TSHR 1539/4885CA2 3485/4885ALOX15 4353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.