Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 2/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7045469 | 1.00 | DRD2 (0.43) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL14063609 | 0.96 | DRD2 (0.40) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL7044387 | 0.82 | CA1 (0.35) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL5620504 | 0.81 | GRIN2B (0.46) | PDE4APDE4BPDE4CPDE4DCMA1 | |
| SCHEMBL3656926 | 0.79 | DRD2 (0.39) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL3656922 | 0.79 | DRD2 (0.39) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL5889322 | 0.77 | GRIN2B (0.49) | PDE4APDE4BPDE4CPDE4DCMA1 | |
| SCHEMBL4148437 | 0.77 | GRIN2B (0.49) | PDE4APDE4BPDE4CPDE4DCMA1 | |
| SCHEMBL7041726 | 0.76 | CA2 (0.41) | PDE4APDE4BPDE4CPDE4DHDAC2 | |
| SCHEMBL22190351 | 0.75 | PARP1 (0.48) | PDE4APDE4BPDE4CPDE4DCMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217592-A1 | BIPHENYL DERIVATIVES AS MODULATORS OF THE HISTAMINE-H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2010-08-18 | — | — | EP | disclosed |
| US-7659294-B2 | 2-(aryl)azacyclylmethyl carboxylates, sulfonates, phosphonates, phosphinates and heterocycles as S1P receptor agonists | MERCK & CO., INC. (US) | 2010-02-09 | — | — | US | disclosed |
| WO-2009058300-A1 | BIPHENYL DERIVATIVES AS MODULATORS OF THE HISTAMINE-H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2009-05-07 | — | — | WO | disclosed |
| US-20090042954-A1 | 2-(Aryl)Azacyclylmethyl Carboxylates, Sulfonates, Phosphonates, Phosphinates and Heterocycles as S1p Receptor Antagonists | MERCK SHARP & DOHME CORP. | 2009-02-12 | — | — | US | disclosed |
| US-7122506-B2 | Cyclic imines as pesticides | BAYER AKTIENGESELLSCHAFT (DE) | 2006-10-17 | — | — | US | disclosed |
| EP-1077938-B1 | 2-(2-METHYLPHENYL)-3,4-DIHYDRO-2H-PYRROL DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2005-04-13 | — | — | EP | disclosed |
| US-20040186287-A1 | Cyclic imines as pesticides | PLANT ANDREW (DE) | 2004-09-23 | — | — | US | disclosed |
| US-20040152904-A1 | Delta1 pyrrolines | BAYER CROPSCIENCE AG (DE) | 2004-08-05 | — | — | US | disclosed |
| EP-1080072-B1 | 2-(2-CHLOROPHENYL)-3,4-DIHYDRO-2H-PYRROL DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2004-08-04 | — | — | EP | disclosed |
| US-6770595-B2 | ACTIVITY AGAINST ARTHROPODS IN AGRICULTURE AND PARASITES ENCOUNTERED IN ANIMAL HUSBANDRY | BAYER AKTIENGESELLSCHAFT (DE) | 2004-08-03 | — | — | US | disclosed |
| WO-2002024644-A1 | DELTA 1-PYRROLINES FOR USE AS PESTICIDES | BAYER CROPSCIENCE AG (DE) | 2002-03-28 | — | — | WO | disclosed |
| US-6274613-B1 | APPLYING COMPOUNDS SUCH AS A GAMMA-ETHOXY-GAMMA-BUTYROLACTAM TO PESTS AND/OR THEIR HABITATS | BAYER AKTIENGESELLSCHAFT (DE) | 2001-08-14 | — | — | US | disclosed |
| EP-1121357-A1 | 2-HETARYL-3,4-DIHYDRO-2H-PYRROLE DERIVATIVES | Bayer Aktiengesellschaft (DE) | 2001-08-08 | — | — | EP | disclosed |
| EP-1080072-A1 | 2-(2-CHLOROPHENYL)-3,4-DIHYDRO-2H-PYRROL DERIVATIVES | Bayer Aktiengesellschaft (DE) | 2001-03-07 | — | — | EP | disclosed |
| EP-1077938-A1 | 2-(2-METHYLPHENYL)-3,4-DIHYDRO-2H-PYRROL DERIVATIVES | BAYER AG (DE) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000021958-A1 | 2-HETARYL-3,4-DIHYDRO-2H-PYRROLE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2000-04-20 | — | — | WO | disclosed |
| WO-1999059968-A1 | 2-(2-CHLOROPHENYL)-3,4-DIHYDRO-2H-PYRROL DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 1999-11-25 | — | — | WO | disclosed |
| WO-1999059967-A1 | 2-(2-METHYLPHENYL)-3,4-DIHYDRO-2H-PYRROL DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 1999-11-25 | — | — | WO | disclosed |
| EP-0942901-A1 | CYCLIC IMINES AS PESTICIDES | BAYER AG (DE) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998022438-A1 | CYCLIC IMINES AS PESTICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1998-05-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152904-A1 | Delta1 pyrrolines | AP3D1, OPRD1, PRMT1 | DRD2 224/4885DRD3 209/4885DRD1 28/4885 |
| US-20040186287-A1 | Cyclic imines as pesticides | DDT, CYP1A1, AR | DRD2 409/4885DRD3 220/4885DRD1 49/4885 |
| US-20090042954-A1 | 2-(Aryl)Azacyclylmethyl Carboxylates, Sulfonates, Phosphonates, Phosphinates and Heterocycles as S1p Receptor Antagonists | S1PR1, S1PR3, S1PR5 | DRD2 2840/4885DRD3 2198/4885DRD1 2355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.