Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.61 |
| ▸ | MAPT | P10636 | 7/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | FHIT | P49789 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.40 |
| ▸ | GRM6 | O15303 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27475039 | 0.84 | ALDH1A1 (0.47) | ALDH1A1MAPTLMNAADORA1GAA | |
| SCHEMBL3451713 | 0.82 | ALDH1A1 (0.56) | ALDH1A1MAPTLMNAADORA1GAA | |
| SCHEMBL20831152 | 0.82 | ALDH1A1 (0.56) | ALDH1A1MAPTLMNAADORA1GAA | |
| SCHEMBL2807538 | 0.80 | CISD2 (0.51) | ALDH1A1MAPTLMNAADORA1GAA | |
| SCHEMBL28773543 | 0.78 | ALDH1A1 (0.41) | ALDH1A1MAPTLMNAADORA1GAA | |
| SCHEMBL8304526 | 0.78 | POLB (0.52) | ALDH1A1MAPTLMNAGAAPOLB | |
| SCHEMBL1063435 | 0.77 | KDM4E (0.60) | ALDH1A1MAPTLMNAGAAPOLB | |
| SCHEMBL1622729 | 0.77 | ALDH1A1 (0.51) | ALDH1A1MAPTLMNAADORA1GAA | |
| SCHEMBL3066973 | 0.77 | ALDH1A1 (0.62) | ALDH1A1MAPTLMNAADORA1GAA | |
| SCHEMBL1638729 | 0.77 | ALDH1A1 (1.00) | ALDH1A1MAPTLMNAADORA1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230278978-A1 | THIOPHENE HSD17B13 INHIBITORS AND USES THEREOF | INIPHARM, INC. | 2023-09-07 | — | — | US | disclosed |
| US-20230278978-A1 | THIOPHENE HSD17B13 INHIBITORS AND USES THEREOF | INIPHARM, INC. | 2023-09-07 | — | — | US | disclosed |
| US-20230278978-A1 | THIOPHENE HSD17B13 INHIBITORS AND USES THEREOF | INIPHARM, INC. | 2023-09-07 | — | — | US | disclosed |
| CN-116323578-A | Thiophene HSD17B13 inhibitor and application thereof | 伊尼制药公司 | 2023-06-23 | — | — | CN | disclosed |
| EP-4185381-A1 | THIOPHENE HSD17B13 INHIBITORS AND USES THEREOF | Inipharm, Inc. (US) | 2023-05-31 | — | — | EP | disclosed |
| CN-110357789-B | N-substituted acrylamide derivative as DHODH inhibitor and preparation and application thereof | 华东理工大学 | 2022-09-30 | — | — | CN | disclosed |
| US-20220081427-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | IMAGO PHARMACEUTICALS, INC. (US) | 2022-03-17 | — | — | US | disclosed |
| US-20200277285-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | IMAGO PHARMACEUTICALS, INC. (US) | 2020-09-03 | — | — | US | disclosed |
| US-20200039972-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | IMAGO PHARMACEUTICALS, INC. (US) | 2020-02-06 | — | — | US | disclosed |
| WO-2019196714-A1 | N-SUBSTITUTED ACRYLAMIDE DERIVATIVE AS DHODH INHIBITOR, AND PREPARATION AND USE THEREOF | 华东理工大学 | 2019-10-17 | — | — | WO | disclosed |
| EP-0025643-B1 | OXO-PYRIDO(1,2-A)THIENOPYRIMIDINE COMPOUNDS, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1983-08-17 | — | — | EP | disclosed |
| US-4332947-A | TREATMENT OF ALLERGIES | WARNER-LAMBERT COMPANY (US) | 1982-06-01 | — | — | US | disclosed |
| US-4287340-A | USEFUL AS ANTIALLERGENS | WARNER-LAMBERT COMPANY (US) | 1981-09-01 | — | — | US | disclosed |
| EP-0025643-A1 | Oxo-pyrido(1,2-a)thienopyrimidine compounds, processes for their production, and pharmaceutical compositions containing said compounds | WARNER-LAMBERT COMPANY (US) | 1981-03-25 | — | — | EP | disclosed |
| US-4230707-A | ANTIALLERGENS | WARNER-LAMBERT COMPANY (US) | 1980-10-28 | — | — | US | disclosed |
| US-4222946-A | ANTIALLERGEN, HYPERSENSITIVITY | LILLY INDUSTRIES, LIMITED (GB) | 1980-09-16 | — | — | US | disclosed |
| US-4187232-A | ANTIALLERGENS | LILLY INDUSTRIES LIMITED (GB) | 1980-02-05 | — | — | US | disclosed |
| US-4079060-A | Thienopyridine-carboxylic acid derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JA) | 1978-03-14 | — | — | US | disclosed |
| US-3997545-A | Thienopyridine-carboxylic acid derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JA) | 1976-12-14 | — | — | US | disclosed |
| US-3951989-A | Thienopyridine-carboxylic acid derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JA) | 1976-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200039972-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | CHUK, MAPK6, MAPK3 | ALDH1A1 4529/4885MAPT 51/4885LMNA 1592/4885 |
| US-20230278978-A1 | THIOPHENE HSD17B13 INHIBITORS AND USES THEREOF | HSD17B3, HSD17B1, HSD17B13 | ALDH1A1 237/4885MAPT 2171/4885LMNA 3376/4885 |
| US-20220081427-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | CHUK, MAPK6, MAPK3 | ALDH1A1 4529/4885MAPT 51/4885LMNA 1592/4885 |
| US-20200277285-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | CHUK, MAPK6, MAPK3 | ALDH1A1 4529/4885MAPT 51/4885LMNA 1592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.