Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KISS1R | Q969F8 | 19/20 | 0.58 |
| ▸ | ECE1 | P42892 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29794137 | 0.94 | GHSR (0.57) | KISS1RECE1 | |
| SCHEMBL28664025 | 0.92 | ECE1 (0.59) | KISS1RECE1 | |
| SCHEMBL28664028 | 0.92 | ECE1 (0.59) | KISS1RECE1 | |
| SCHEMBL30436748 | 0.91 | KISS1R (0.60) | KISS1RECE1 | |
| SCHEMBL30522762 | 0.91 | ECE1 (0.58) | KISS1RECE1 | |
| SCHEMBL31229004 | 0.91 | ERAP2 (0.62) | KISS1RECE1 | |
| SCHEMBL29794156 | 0.90 | ERAP2 (0.55) | KISS1RECE1 | |
| SCHEMBL30464865 | 0.90 | NPY4R (0.61) | KISS1RECE1 | |
| SCHEMBL29389812 | 0.89 | NPY1R (0.56) | KISS1RECE1 | |
| SCHEMBL29825066 | 0.89 | NPY4R (0.61) | KISS1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160241-A1 | NOVEL COMPOUND HAVING GPR54 AGONISTIC ACTIVITY | KYOTO UNIVERSITY (JP) | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160241-A1 | NOVEL COMPOUND HAVING GPR54 AGONISTIC ACTIVITY | GPR52, GPR84, GPR4 | KISS1R 160/4885ECE1 2310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.