Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.67 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.67 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.67 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.67 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.67 |
| ▸ | PKM | P14618 | 3/20 | 0.65 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | IDE | P14735 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | HLCS | P50747 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 2/20 | 0.58 |
| ▸ | CA1 | P00915 | 2/20 | 0.58 |
| ▸ | CA2 | P00918 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24766888 | 1.00 | F2 (0.67) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL18549029 | 0.99 | F2 (0.69) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL31578516 | 0.99 | F2 (0.69) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL30735826 | 0.99 | F2 (0.69) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL24514747 | 0.99 | F2 (0.69) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL18550538 | 0.99 | F2 (0.69) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL31479957 | 0.99 | F2 (0.69) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL24767163 | 0.99 | F2 (0.69) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL22767679 | 0.99 | F2 (0.69) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL29485943 | 0.99 | F2 (0.69) | F2PRSS1PRSS2PRSS3TPSAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240084377-A1 | METHODS FOR THE SEQUENCING OF PHOSPHORODIAMIDATE MORPHOLINO OLIGOMERS (PMO) AND PEPTIDE-PMO (PPMO) CONJUGATES | ENTRADA THERAPEUTICS, INC. | 2024-03-14 | — | — | US | disclosed |
| CN-116042675-A | Method for high-efficiency recombinant expression and protein purification of ADP-ribosyl cyclase | 上海观龄基因科技有限公司 | 2023-05-02 | — | — | CN | disclosed |
| EP-3524604-B1 | EXPANDED HEMATOPOIETIC STEM CELLS FROM CORD BLOOD AND THEIR THERAPEUTIC USE | NOVARTIS AG (CH) | 2023-03-29 | — | — | EP | disclosed |
| WO-2022098662-A2 | METHODS AND COMPOSITIONS RELATING TO CHEMOKINE RECEPTOR VARIANTS | Twist Bioscience Corporation (US) | 2022-05-12 | — | — | WO | disclosed |
| US-20220135690-A1 | METHODS AND COMPOSITIONS RELATING TO CHEMOKINE RECEPTOR VARIANTS | TWIST BIOSCIENCE CORP (US) | 2022-05-05 | — | — | US | disclosed |
| US-20210187033-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | NOVARTIS AG (CH) | 2021-06-24 | — | — | US | disclosed |
| EP-3524604-A1 | EXPANDED HEMATOPOIETIC STEM CELLS FROM CORD BLOOD AND THEIR THERAPEUTIC USE | Novartis AG (CH) | 2019-08-14 | — | — | EP | disclosed |
| EP-2350078-B1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | NOVARTIS AG (CH) | 2019-04-17 | — | — | EP | disclosed |
| US-20180142212-A1 | COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS | FRED HUTCHINSON CANCER RESEARCH CENTER | 2018-05-24 | — | — | US | disclosed |
| US-20170239296-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | NOVARTIS AG (CH) | 2017-08-24 | — | — | US | disclosed |
| US-20150346209-A1 | METHOD OF LABELING SULFENIC ACID-CONTAINING PROTEINS AND PEPTIDES | UNIV WAKE FOREST HEALTH SCIENCES (US) | 2015-12-03 | — | — | US | disclosed |
| US-20150346209-A1 | METHOD OF LABELING SULFENIC ACID-CONTAINING PROTEINS AND PEPTIDES | UNIV WAKE FOREST HEALTH SCIENCES (US) | 2015-12-03 | — | — | US | disclosed |
| US-9175266-B2 | Enhancement of natural killer (NK) cell proliferation and activity | GAMIDA CELL LTD. (IL) | 2015-11-03 | — | — | US | disclosed |
| US-9023653-B2 | Method of labeling sulfenic acid-containing proteins and peptides | WAKE FOREST UNIVERSITY HEALTH SCIENCES (US) | 2015-05-05 | — | — | US | disclosed |
| US-8927281-B2 | Method for expanding hematopoietic stem cells | IRM LLC (BM) | 2015-01-06 | — | — | US | disclosed |
| US-20140114070-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-04-24 | — | — | US | disclosed |
| US-20140023623-A1 | Methods of Culturing and Expanding Mesenchymal Stem Cells and Isolated Cell Populations Generated Thereby | GAMIDA CELL INC. | 2014-01-23 | — | — | US | disclosed |
| US-20140023626-A1 | Enhancement of Natural Killer (NK) Cell Proliferation and Activity | GAMIDA CELL INC. | 2014-01-23 | — | — | US | disclosed |
| US-20130149732-A1 | METHOD OF LABELING SULFENIC ACID-CONTAINING PROTEINS AND PEPTIDES | FURDUI CRISTINA M (US) | 2013-06-13 | — | — | US | disclosed |
| US-20100183564-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | IRM LLC (BM) | 2010-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170239296-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | CD47, HCLS1, CD74 | F2 3954/4885PRSS1 2911/4885PRSS2 4177/4885 |
| US-20210187033-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | CD47, HCLS1, CD74 | F2 3954/4885PRSS1 2911/4885PRSS2 4177/4885 |
| US-20140114070-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | CD47, HCLS1, CD74 | F2 3954/4885PRSS1 2911/4885PRSS2 4177/4885 |
| US-20140023626-A1 | Enhancement of Natural Killer (NK) Cell Proliferation and Activity | PBK, IL2, AHR | F2 3820/4885PRSS1 927/4885PRSS2 2079/4885 |
| US-20100183564-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | CD47, HCLS1, CD74 | F2 3954/4885PRSS1 2911/4885PRSS2 4177/4885 |
| US-20150346209-A1 | METHOD OF LABELING SULFENIC ACID-CONTAINING PROTEINS AND PEPTIDES | CTH, PTMS, CBS | F2 3853/4885PRSS1 1128/4885PRSS2 779/4885 |
| US-20140023623-A1 | Methods of Culturing and Expanding Mesenchymal Stem Cells and Isolated Cell Populations Generated Thereby | AHR, HGF, MTNR1A | F2 4807/4885PRSS1 674/4885PRSS2 683/4885 |
| US-20180142212-A1 | COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS | AHR, NOTCH1, ARNT | F2 2251/4885PRSS1 1962/4885PRSS2 2855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.