Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 7/20 | 0.42 |
| ▸ | MAOB | P27338 | 7/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | NAT1 | P18440 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3517696 | 0.88 | ALDH1A1 (0.40) | MAOBOPRM1OPRD1MAPTNPC1 | |
| SCHEMBL3519074 | 0.86 | PIK3CD (0.44) | OPRM1OPRD1MAPTNPC1RAB9A | |
| SCHEMBL4469363 | 0.84 | MAOA (0.42) | MAOAMAOBAXLNAT1OPRM1 | |
| SCHEMBL3514697 | 0.82 | DRD2 (0.44) | MAPTNPC1RAB9AALDH1A1TSHR | |
| SCHEMBL3516281 | 0.79 | GRK2 (0.42) | OPRM1OPRD1ALDH1A1TSHR | |
| SCHEMBL3514797 | 0.77 | AXL (0.39) | AXLNAT1NPC1RAB9AMEN1 | |
| SCHEMBL3515379 | 0.76 | KDM4E (0.45) | MAOBOPRM1OPRD1MAPTNPC1 | |
| SCHEMBL3514631 | 0.76 | ALDH1A1 (0.41) | OPRM1OPRD1MAPTNPC1RAB9A | |
| SCHEMBL3515597 | 0.74 | ALDH1A1 (0.42) | MAPTNPC1RAB9AALDH1A1TSHR | |
| SCHEMBL16274641 | 0.73 | CYP1A2 (0.41) | MAOBALDH1A1TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | RNASEH1, RNASE1, RNASEL | MAOA 1143/4885MAOB 1186/4885AXL 4664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.