Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 6/20 | 0.46 |
| ▸ | GRIK2 | Q13002 | 6/20 | 0.46 |
| ▸ | GRIK5 | Q16478 | 6/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 6/20 | 0.46 |
| ▸ | GRIA2 | P42262 | 6/20 | 0.46 |
| ▸ | GRIA4 | P48058 | 6/20 | 0.46 |
| ▸ | GRIA3 | P42263 | 5/20 | 0.46 |
| ▸ | GRIK3 | Q13003 | 5/20 | 0.46 |
| ▸ | GRIK4 | Q16099 | 3/20 | 0.46 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5797007 | 0.75 | CFTR (0.50) | — | |
| SCHEMBL2153695 | 0.75 | SLC9A1 (0.63) | GRIA1GRIA2GRIA4GRIA3APEX1 | |
| SCHEMBL17870732 | 0.75 | FPR1 (0.42) | GRIA1GRIA2GRIA4GRIA3APEX1 | |
| SCHEMBL26948700 | 0.74 | ADORA2B (0.42) | — | |
| SCHEMBL21685452 | 0.73 | TSHR (0.41) | GRIK1GRIK2GRIK5GRIA1GRIA2 | |
| SCHEMBL7366632 | 0.72 | ADORA2B (0.43) | GRIK1GRIK2GRIK5GRIA1GRIA2 | |
| SCHEMBL136441 | 0.71 | SLC9A1 (0.41) | GRIA1GRIA2GRIA4GRIA3APEX1 | |
| SCHEMBL261099 | 0.71 | APEX1 (0.47) | GRIK1GRIK2GRIK5GRIA1GRIA2 | |
| SCHEMBL25183490 | 0.69 | ALDH1A1 (0.41) | GRIA1GRIA2GRIA4GRIA3APEX1 | |
| SCHEMBL11480035 | 0.68 | KDM4E (0.50) | GRIK1GRIK2GRIK5GRIA1GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040058964-A1 | Substituted pyridinones | PHARMACIA LLC | 2004-03-25 | — | — | US | claimed |
| US-7795271-B2 | Substituted pyrimidinones | PHARMACIA CORPORATION (US) | 2010-09-14 | — | — | US | disclosed |
| US-20090306108-A1 | SUBSTITUTED PYRIMIDINONES | PFIZER INC | 2009-12-10 | — | — | US | disclosed |
| US-7629363-B2 | antiinflammatory agent for treating asthma and chronic pulmonary inflammatory disease | PFIZER INC (US) | 2009-12-08 | — | — | US | disclosed |
| US-20070167621-A1 | SUBSTITUTED PYRIMIDINONES | PHARMACIA CORPORATION (US) | 2007-07-19 | — | — | US | disclosed |
| US-7183287-B2 | Substituted pyrimidinones | PHARMACIA CORPORATION (US) | 2007-02-27 | — | — | US | disclosed |
| WO-2005018557-A2 | SUBSTITUTED PYRIDINONES | PHARMACIA CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |
| US-20040242608-A1 | Substituted pyrimidinones | PHARMACIA LLC | 2004-12-02 | — | — | US | disclosed |
| US-20040058964-A1 | Substituted pyridinones | PHARMACIA LLC | 2004-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058964-A1 | Substituted pyridinones | MAPK1, MAPK6, MAPK7 | GRIK1 919/4885GRIK2 1512/4885GRIK5 669/4885 |
| US-20090306108-A1 | SUBSTITUTED PYRIMIDINONES | MAPK1, MAP3K8, MAP3K7 | GRIK1 1500/4885GRIK2 1883/4885GRIK5 1421/4885 |
| US-20040242608-A1 | Substituted pyrimidinones | MAPK1, MAPK7, MAP3K8 | GRIK1 1123/4885GRIK2 1642/4885GRIK5 1054/4885 |
| US-20070167621-A1 | SUBSTITUTED PYRIMIDINONES | MAPK1, MAP3K8, MAP3K7 | GRIK1 1500/4885GRIK2 1883/4885GRIK5 1421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.