SCHEMBL352595

SCHEMBL352595

O=S(=O)(O)c1c(O)c(F)c(F)c(F)c1F

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 5/20 0.44
CA2 P00918 5/20 0.44
MMP1 P03956 1/20 0.42
MMP2 P08253 1/20 0.42
MMP9 P14780 1/20 0.42
MMP8 P22894 1/20 0.42
MMP13 P45452 1/20 0.42
CA12 O43570 2/20 0.42
CA7 P43166 2/20 0.42
CA13 Q8N1Q1 2/20 0.42
F2 P00734 3/20 0.38
PRSS1 P07477 3/20 0.38
PRSS2 P07478 3/20 0.38
PRSS3 P35030 3/20 0.38
DAPK1 P53355 1/20 0.32
FABP3 P05413 1/20 0.31
FABP4 P15090 1/20 0.31
FABP5 Q01469 1/20 0.31
CA3 P07451 1/20 0.30
CA4 P22748 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL998025 0.86 CA1 (0.41) CA1CA2MMP1MMP2MMP9
SCHEMBL4578502 0.84 CA1 (0.39) CA1CA2MMP1MMP2MMP9
SCHEMBL31388915 0.84 CA1 (0.39) CA1CA2MMP1MMP2MMP9
SCHEMBL23340283 0.84 CA1 (0.39) CA1CA2MMP1MMP2MMP9
SCHEMBL36242 0.83 CA2 (0.52) CA1CA2MMP1MMP2MMP9
SCHEMBL758511 0.83 CA2 (0.52) CA1CA2MMP1MMP2MMP9
SCHEMBL12308132 0.81 CA1 (0.34) CA1CA2MMP1MMP2MMP9
Ammonia Solution, Strong SCHEMBL21384843 0.80 CA2 (0.50) CA1CA2MMP1MMP2MMP9
SCHEMBL21522547 0.80 CA2 (0.50) CA1CA2MMP1MMP2MMP9
SCHEMBL21522351 0.80 CA2 (0.50) CA1CA2MMP1MMP2MMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 95 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180362766-A1 Fluorogenic pH-Sensitive Dyes and Their Methods of Use Life Technologies Corporation 2018-12-20 US claimed
US-20170145214-A1 FLUOROGENIC PH-SENSITIVE DYES AND THEIR METHODS OF USE (II) Life Technologies Corporation 2017-05-25 US claimed
US-9599622-B2 Fluorogenic pH-sensitive dyes and their methods of use (II) Life Technologies Corporation (US) 2017-03-21 US claimed
US-20150241438-A1 Fluorogenic pH-Sensitive Dyes and Their Methods of Use Life Technologies Corporation 2015-08-27 US claimed
US-20150218379-A1 Fluorogenic pH-Sensitive Dyes and Their Methods of Use (II) Life Technologies Corporation 2015-08-06 US claimed
EP-2875075-A1 FLUOROGENIC PH-SENSITIVE DYES AND THEIR METHODS OF USE (II) Life Technologies Corporation (US) 2015-05-27 EP claimed
EP-2855596-A1 FLUOROGENIC pH-SENSITIVE DYES AND THEIR METHODS OF USE Life Technologies Corporation (US) 2015-04-08 EP claimed
WO-2013180813-A1 FLUOROGENIC PH-SENSITIVE DYES AND THEIR METHODS OF USE (II) Life Technologies Corporation (US) 2013-12-05 WO claimed
WO-2013180811-A1 FLUOROGENIC pH-SENSITIVE DYES AND THEIR METHODS OF USE Life Technologies Corporation (US) 2013-12-05 WO claimed
WO-2010111664-A1 IMPROVED METHOD TO DETERMINE PROTEIN INTERACTION SITES INSTITUTE FOR SYSTEMS BIOLOGY (US) 2010-09-30 WO claimed
US-12497515-B2 Fluorogenic pH-sensitive compounds and their methods of use Life Technologies Corporation (US) 2025-12-16 US disclosed
US-20240228785-A1 Fluorogenic pH-Sensitive Compounds and Their Methods of Use Life Technologies Corporation 2024-07-11 US disclosed
US-11952495-B1 Fluorogenic pH-sensitive compounds and their methods of use Life Technologies Corporation (US) 2024-04-09 US disclosed
US-20240065990-A1 METHODS, COMPOUNDS, COMPOSITIONS AND VEHICLES FOR DELIVERING 3-AMINO-1-PROPANESULFONIC ACID BELLUS HEALTH INC (CA) 2024-02-29 US disclosed
EP-3851447-B1 METHODS, COMPOUNDS, COMPOSITIONS AND VEHICLES FOR DELIVERING 3-AMINO-1-PROPANESULFONIC ACID BELLUS HEALTH INC (CA) 2023-09-06 EP disclosed
WO-2004113277-A2 METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES NEUROCHEM (INTERNATIONAL) LIMITED (CH) 2004-12-29 WO disclosed
EP-1476753-A2 FUNCTIONALIZED COMPOSITIONS FOR IMPROVED IMMOBILIZATION Luminex Corporation (US) 2004-11-17 EP disclosed
WO-2004092707-A2 AROMATIC PHOSPHONIUM SALTS AND THEIR USE AS LABELING REAGENTS MASS SPECTROMETRY ANALYSIS WATERS INVESTMENTS LIMITED (US) 2004-10-28 WO disclosed
US-20040039201-A1 Functionalized compositions for improved immobilization LUMINEX CORPORATION 2004-02-26 US disclosed
WO-2003084982-A2 FUNCTIONALIZED COMPOSITIONS FOR IMPROVED IMMOBILIZATION LUMINEX CORPORATION (US) 2003-10-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240065990-A1 METHODS, COMPOUNDS, COMPOSITIONS AND VEHICLES FOR DELIVERING 3-AMINO-1-PROPANESULFONIC ACID APP, PSEN1, PSEN2 CA1 109/4885CA2 1611/4885MMP1 775/4885
US-20180362766-A1 Fluorogenic pH-Sensitive Dyes and Their Methods of Use ALPG, XDH, HEXD CA1 339/4885CA2 401/4885MMP1 1514/4885
US-20150241438-A1 Fluorogenic pH-Sensitive Dyes and Their Methods of Use ALPG, XDH, HEXD CA1 339/4885CA2 401/4885MMP1 1514/4885
US-20040039201-A1 Functionalized compositions for improved immobilization ILK, EPCAM, ICAM1 CA1 431/4885CA2 629/4885MMP1 3056/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.