Water

Water

SCHEMBL3526962

O.c1ccc2c(c1)N2

nearest known ligand 0.00

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2676730 0.96 GAA (0.59)
SCHEMBL624418 0.96 GAA (0.59)
SCHEMBL76607 0.96
SCHEMBL29369547 0.96 GAA (0.59)
Fluoride SCHEMBL6264312 0.92
SCHEMBL7171963 0.92 GAA (0.56)
Naphthalene SCHEMBL5071443 0.85 ALOX12 (0.57)
Formaldehyde SCHEMBL1144590 0.85
SCHEMBL12263849 0.80 NOX1 (0.46)
SCHEMBL30127774 0.77 NOX1 (0.58)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5721200-A REACTING OLEFINIC COPLYMER WITH UNSATURATED ACYLATING AGENT TO FROM A GRAFT COPOLYMER AND REDUCING MOLECULAR WEIGHT, REACTING GRAFTED COPOLYMER WITH AMINO-ALCOHOL COMPOUND DSM COPOLYMER, INC. (US) 1998-02-24 US claimed
US-5474694-A Dispersant additive which is an modified alpha-olefin polymer TEXACO INC. (US) 1995-12-12 US claimed
US-10562878-B2 Cycloalkylamines as monoamine reuptake inhibitors SUNOVION PHARAMCEUTICALS INC. (US) 2020-02-18 US disclosed
US-9868718-B2 Cycloalkylamines as monoamine reuptake inhibitors SUNOVION PHARMACEUTICALS INC. (US) 2018-01-16 US disclosed
EP-1976513-B1 CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS SUNOVION PHARMACEUTICALS INC (US) 2016-08-24 EP disclosed
US-20150126511-A1 CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS SUNOVION PHARMACEUTICALS INC. 2015-05-07 US disclosed
US-8877975-B2 Cycloalkylamines as monoamine reuptake inhibitors SUNOVION PHARMACEUTICALS INC. (US) 2014-11-04 US disclosed
US-20100190861-A1 CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS SUNOVION PHARMACEUTICALS INC. 2010-07-29 US disclosed
EP-1976513-A2 CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS Sepracor, Inc. (US) 2008-10-08 EP disclosed
US-20070203111-A1 Cycloalkylamines as monoamine reuptake inhibitors SEPRACOR INC. (US) 2007-08-30 US disclosed
WO-2007081857-A2 CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS SEPRACOR INC. (US) 2007-07-19 WO disclosed
WO-2001049761-A1 COMPOSITIONS COMPRISING ANTIOXIDANT AMINES BASED ON N-(4-ANILINOPHENYL)AMIDES UNIROYAL CHEMICAL COMPANY, INC. (US) 2001-07-12 WO disclosed
US-RE37105-E1 GRAFT POLYMER UNIROYAL CHEMICAL COMPANY, INC. 2001-03-20 US disclosed
EP-0961789-A1 LUBRICANTS CONTAINING ASHLESS ANTIWEAR-DISPERSANT ADDITIVE HAVING VISCOSITY INDEX IMPROVER CREDIT UNIROYAL CHEMICAL COMPANY, Inc. (US) 1999-12-08 EP disclosed
WO-1998033828-A1 LUBRICANTS CONTAINING ASHLESS ANTIWEAR-DISPERSANT ADDITIVE HAVING VISCOSITY INDEX IMPROVER CREDIT UNIROYAL CHEMICAL COMPANY, INC. (US) 1998-08-06 WO disclosed
US-5721200-A REACTING OLEFINIC COPLYMER WITH UNSATURATED ACYLATING AGENT TO FROM A GRAFT COPOLYMER AND REDUCING MOLECULAR WEIGHT, REACTING GRAFTED COPOLYMER WITH AMINO-ALCOHOL COMPOUND DSM COPOLYMER, INC. (US) 1998-02-24 US disclosed
US-5721200-A REACTING OLEFINIC COPLYMER WITH UNSATURATED ACYLATING AGENT TO FROM A GRAFT COPOLYMER AND REDUCING MOLECULAR WEIGHT, REACTING GRAFTED COPOLYMER WITH AMINO-ALCOHOL COMPOUND DSM COPOLYMER, INC. (US) 1998-02-24 US disclosed
US-5698500-A POLYMER CONTAINING ETHYLENE, AN ALPHA MONOOLEFIN AND A POLYENE WITH A 2-MERCAPTO-1,3,4-THIADIAZOLE MOIETY GRAFTED THEREON UNIROYAL CHEMICAL COMPANY, INC. (US) 1997-12-16 US disclosed
US-5474694-A Dispersant additive which is an modified alpha-olefin polymer TEXACO INC. (US) 1995-12-12 US disclosed
US-5474694-A Dispersant additive which is an modified alpha-olefin polymer TEXACO INC. (US) 1995-12-12 US disclosed