Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 8/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | LOX | P28300 | 2/20 | 0.53 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3531425 | 0.93 | GAA (0.54) | GAAKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL3532077 | 0.84 | KMT2A (0.64) | GAAKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL3531736 | 0.83 | KMT2A (0.44) | GAAKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL3535982 | 0.82 | KMT2A (0.47) | GAAKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL3537137 | 0.79 | HCAR1 (0.41) | GAAKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL3529002 | 0.78 | KMT2A (0.47) | GAAKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL3532127 | 0.78 | MAPT (0.45) | GAAKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL7400667 | 0.77 | GAA (0.62) | GAAKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL3529723 | 0.76 | SHMT2 (0.43) | GAAKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL3529328 | 0.76 | ALDH1A1 (0.60) | GAAKMT2AMAPTMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113200993-A | Synthesis method of oxindole spirodihydrofuran compound | 浙江工业大学 | 2021-08-03 | — | — | CN | disclosed |
| CN-101243050-B | Pyrazolone derivatives | HOFFMANN LA ROCHE | 2012-07-04 | — | — | CN | disclosed |
| US-7652057-B2 | Pyrazolones as 11b-HSD1 inhibitors for diabetes | HOFFMAN-LA ROCHE INC. (US) | 2010-01-26 | — | — | US | disclosed |
| CN-101243050-A | Pyrazolone derivatives | HOFFMANN LA ROCHE (CH) | 2008-08-13 | — | — | CN | disclosed |
| EP-1924562-A2 | PYRAZOLONE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007025880-A2 | PYRAZOLONE DERIVATIVES AS 11-BETA HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |
| US-20070049574-A1 | New pyrazolones as 11b-HSD1 inhibitors for diabetes | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049574-A1 | New pyrazolones as 11b-HSD1 inhibitors for diabetes | HSD11B1, HSD17B1, HSD17B7 | GAA 2764/4885KMT2A 4086/4885MAPT 3706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.