SCHEMBL353826

SCHEMBL353826

Sc1nccn1-c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 7/20 0.50
L3MBTL1 Q9Y468 5/20 0.50
CYP1A2 P05177 5/20 0.50
CYP2D6 P10635 5/20 0.50
CYP2C9 P11712 5/20 0.50
CYP2C19 P33261 5/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
RAB9A P51151 2/20 0.50
NPC1 O15118 1/20 0.50
ALOX15B O15296 3/20 0.46
GAA P10253 1/20 0.46
FDPS P14324 1/20 0.44
ALDH1A1 P00352 4/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
POLB P06746 1/20 0.40
CYP2E1 P05181 1/20 0.40
CYP2A6 P11509 1/20 0.40
HTT P42858 1/20 0.39
FGFR1 P11362 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2269279 0.98 CYP3A4 (0.49) CYP3A4L3MBTL1CYP1A2CYP2D6CYP2C9
SCHEMBL28750395 0.84 FAAH (0.41) CYP3A4L3MBTL1CYP1A2CYP2D6CYP2C9
SCHEMBL9802365 0.83 MAPK9 (0.37) CYP3A4L3MBTL1CYP1A2CYP2D6CYP2C9
SCHEMBL5648367 0.82 CYP2A6 (0.62) CYP3A4CYP1A2ALDH1A1CYP2E1CYP2A6
SCHEMBL23196722 0.79 CYP3A4 (0.44) CYP3A4L3MBTL1CYP1A2CYP2D6CYP2C9
SCHEMBL6609392 0.79 MAPKAPK2 (0.43) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL6608437 0.79 NOTUM (0.41) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL10594306 0.79 ENPP2 (0.41) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL6177595 0.79 MKNK1 (0.43) CYP3A4L3MBTL1CYP1A2CYP2D6CYP2C9
SCHEMBL17153773 0.79 MAPK1 (0.51) FGFR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 140 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0318758-A2 Multilayered electrophotographical recording material BASF Aktiengesellschaft (DE) 1989-06-07 EP claimed
US-4286045-A A SUPPORT HAVING A LAYER OF A CHALCOGENIDE OF GERMANIUM DOPED WITH SILVER OR COPPER; STABILITY; LITHOGRAPHIC PRINTING PLATES FUJI PHOTO FILM CO., LTD. (JP) 1981-08-25 US claimed
US-4198237-A GERMANIUM SULFIDE FUJI PHOTO FILM CO., LTD. (JP) 1980-04-15 US claimed
JP-5124923-A None JP disclosed
JP-4323659-A None JP disclosed
US-20240148744-A1 SULFONAMIDES AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES ZOETIS LLC 2024-05-09 US disclosed
EP-4291555-A1 SULFONAMIDES AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES Celgene Corporation (US) 2023-12-20 EP disclosed
CN-116806218-A Sulfonamide and its use for the treatment of parasitic helminth infections and diseases 新基公司 2023-09-26 CN disclosed
WO-2022173727-A1 SULFONAMIDES AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES CELGENE CORPORATION (US) 2022-08-18 WO disclosed
EP-2520351-B1 ABSORBING SOLUTION AND RECOVERY METHOD FOR CARBON DIOXIDE MITSUBISHI HITACHI POWER SYS (JP) 2017-03-08 EP disclosed
US-20170020858-A1 COMPOUNDS FOR MODULATING TRPV3 FUNCTION HYDRA BIOSCIENCES INC (US) 2017-01-26 US disclosed
EP-0135786-A2 Photographic image receiving elements for silver salt diffusion transfer processes FUJI PHOTO FILM CO., LTD. (JP) 1985-04-03 EP disclosed
EP-0131311-A2 Image-receiving element for silver salt diffusion process FUJI PHOTO FILM CO., LTD. (JP) 1985-01-16 EP disclosed
EP-0128594-A2 Photographic elements for silver salt diffusion transfer process FUJI PHOTO FILM CO., LTD. (JP) 1984-12-19 EP disclosed
US-4415650-A VACUUM DEPOSITING AN ORGANIC AND AN INORGANIC COMPOUND ON A SUPPORT; THERMOSENSITIVITY; LASERS FUJI PHOTO FILM CO., LTD. (JP) 1983-11-15 US disclosed
US-4286045-A A SUPPORT HAVING A LAYER OF A CHALCOGENIDE OF GERMANIUM DOPED WITH SILVER OR COPPER; STABILITY; LITHOGRAPHIC PRINTING PLATES FUJI PHOTO FILM CO., LTD. (JP) 1981-08-25 US disclosed
US-4198237-A GERMANIUM SULFIDE FUJI PHOTO FILM CO., LTD. (JP) 1980-04-15 US disclosed
US-4197124-A SILVER OR COPPER AND SULFUR, SELENIUM OR TELLURIUM0 FUJI PHOTO FILM CO., LTD. (JP) 1980-04-08 US disclosed
US-4177072-A HYDROPHILIC AND OLEOPHILIC AREAS FUJI PHOTO FILM CO., LTD. (JP) 1979-12-04 US disclosed
US-3996238-A 4- or 5-Nitroimidazoles and processes for their manufacture CIBA-GEIGY CORPORATION (US) 1976-12-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170020858-A1 COMPOUNDS FOR MODULATING TRPV3 FUNCTION TRPV3, TRPV1, TRPV4 CYP3A4 3177/4885L3MBTL1 4457/4885CYP1A2 3450/4885
US-20240148744-A1 SULFONAMIDES AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES ARSA, MRPS2, SULT2A1 CYP3A4 1243/4885L3MBTL1 1807/4885CYP1A2 258/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.