SCHEMBL354166

SCHEMBL354166

COC(=O)c1ccc2c(c1)C(=O)CCC2

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.50
NPSR1 Q6W5P4 2/20 0.50
ATM Q13315 2/20 0.50
ALDH1A1 P00352 1/20 0.50
MEN1 O00255 1/20 0.48
FGB P02675 1/20 0.48
HSP90AA1 P07900 1/20 0.48
HSP90AB1 P08238 1/20 0.48
MAPT P10636 1/20 0.48
HPGD P15428 1/20 0.48
ALOX15 P16050 1/20 0.48
MAPK1 P28482 1/20 0.48
HTT P42858 1/20 0.48
KMT2A Q03164 1/20 0.48
HSD17B10 Q99714 1/20 0.48
BAZ2B Q9UIF8 1/20 0.46
CASP3 P42574 1/20 0.46
BRD4 O60885 1/20 0.45
CA12 O43570 1/20 0.45
CA1 P00915 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29446230 1.00 SMN1; SMN2 (0.50) SMN1; SMN2NPSR1ATMALDH1A1MEN1
SCHEMBL2258053 0.97 ALDH1A1 (0.50) SMN1; SMN2NPSR1ATMALDH1A1MEN1
SCHEMBL484748 0.90 PBRM1 (0.51) SMN1; SMN2NPSR1ATMALDH1A1MAPT
SCHEMBL353895 0.88 BAZ2B (0.56) SMN1; SMN2NPSR1ATMALDH1A1MEN1
SCHEMBL13727452 0.84 BAZ2B (0.52) SMN1; SMN2NPSR1ATMALDH1A1MEN1
SCHEMBL9587300 0.84 SRD5A1 (0.46) SMN1; SMN2NPSR1ATMALDH1A1MEN1
SCHEMBL18159338 0.82 NPC1 (0.53) SMN1; SMN2NPSR1ALDH1A1MEN1MAPT
SCHEMBL883530 0.82 ALDH1A1 (0.61) SMN1; SMN2ATMALDH1A1MEN1MAPT
SCHEMBL9175124 0.81 MAOA (0.40) SMN1; SMN2NPSR1ATMALDH1A1MEN1
SCHEMBL17276101 0.81 MAPT (0.44) SMN1; SMN2NPSR1ATMALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12350270-B2 Antimalarial agents MSD R&D (CHINA) CO. LTD. (CN) 2025-07-08 US disclosed
EP-3145915-B1 ANTIDIABETIC TRICYCLIC COMPOUNDS MERCK SHARP & DOHME LLC (US) 2025-03-19 EP disclosed
US-20230355622-A1 METHODS OF CHEMOVACCINATION AGAINST PLASMODIUM INFECTIONS MERCK SHARP & DOHME LLC (US) 2023-11-09 US disclosed
US-20230355622-A1 METHODS OF CHEMOVACCINATION AGAINST PLASMODIUM INFECTIONS MERCK SHARP & DOHME LLC (US) 2023-11-09 US disclosed
US-20230355622-A1 METHODS OF CHEMOVACCINATION AGAINST PLASMODIUM INFECTIONS MERCK SHARP & DOHME LLC (US) 2023-11-09 US disclosed
EP-4216957-A1 METHODS OF CHEMOVACCINATION AGAINST PLASMODIUM INFECTIONS Merck Sharp & Dohme LLC (US) 2023-08-02 EP disclosed
US-20220331321-A1 ANTIMALARIAL AGENTS MERCK SHARP & DOHME CORP. (US) 2022-10-20 US disclosed
US-20220331321-A1 ANTIMALARIAL AGENTS MERCK SHARP & DOHME CORP. (US) 2022-10-20 US disclosed
CN-114555564-A Antimalarial drugs 默沙东公司 2022-05-27 CN disclosed
WO-2022066545-A1 METHODS OF CHEMOVACCINATION AGAINST PLASMODIUM INFECTIONS MERCK SHARP & DOHME CORP. (US) 2022-03-31 WO disclosed
EP-0699209-A1 PROCESSES AND INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF PLATELET GLYCOPROTEIN IIb/IIIa INHIBITORS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1996-03-06 EP disclosed
EP-0692982-A1 RADIOLABELED PLATELET GPIIb/IIIa RECEPTOR ANTAGONISTS AS IMAGING AGENTS FOR THE DIAGNOSIS OF THROMBOEMBOLIC DISORDERS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1996-01-24 EP disclosed
EP-0691987-A1 CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1996-01-17 EP disclosed
WO-1995023811-A1 NOVEL CARBOCYCLIC COMPOUNDS WHICH INHIBIT PLATELET AGGREGATION BY INTERACTION WITH THE GPIIB/IIIA RECEPTOR COMPLEX THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1995-09-08 WO disclosed
US-5405844-A Tetracyclic antibiotics and processes for their preparation HOECHST AKTIENGESELLSCHAFT (DE) 1995-04-11 US disclosed
WO-1994026779-A1 PROCESSES AND INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF PLATELET GLYCOPROTEIN IIb/IIIa INHIBITORS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1994-11-24 WO disclosed
EP-0625164-A1 CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1994-11-23 EP disclosed
WO-1994022910-A1 CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1994-10-13 WO disclosed
WO-1994022494-A1 RADIOLABELED PLATELET GPIIb/IIIa RECEPTOR ANTAGONISTS AS IMAGING AGENTS FOR THE DIAGNOSIS OF THROMBOEMBOLIC DISORDERS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1994-10-13 WO disclosed
WO-1993007170-A1 CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1993-04-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12350270-B2 Antimalarial agents CTSL, SERPINA3, SERPINB1 SMN1; SMN2 3474/4885NPSR1 2341/4885ATM 4665/4885
US-20230355622-A1 METHODS OF CHEMOVACCINATION AGAINST PLASMODIUM INFECTIONS CTSL, PRCP, CPB1 SMN1; SMN2 4402/4885NPSR1 3039/4885ATM 4353/4885
US-20220331321-A1 ANTIMALARIAL AGENTS CTSL, SERPINA3, SERPINB1 SMN1; SMN2 3474/4885NPSR1 2341/4885ATM 4665/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.