Mangostin

Mangostin

SCHEMBL354735

COc1c(O)cc2oc3cc(O)c(CC=C(C)C)c(O)c3c(=O)c2c1CC=C(C)C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MGAM O43451 7/20 1.00
GAA P10253 7/20 1.00
SI P14410 7/20 1.00
MGAM2 Q2M2H8 7/20 1.00
FASN P49327 5/20 1.00
IDH1 O75874 4/20 1.00
PTPN1 P18031 4/20 1.00
CYP19A1 P11511 4/20 1.00
NUDT1 P36639 4/20 1.00
RELA Q04206 3/20 1.00
SIRT2 Q8IXJ6 3/20 1.00
SMPD1 P17405 3/20 1.00
AKR1B1 P15121 2/20 1.00
PGAM1 P18669 2/20 1.00
PDE4D Q08499 2/20 1.00
KDM4E B2RXH2 2/20 1.00
MAPT P10636 2/20 1.00
MAPK1 P28482 2/20 1.00
MEN1 O00255 1/20 1.00
KDM1A O60341 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Mangostin SCHEMBL29433195 1.00 MGAM (1.00) MGAMGAASIMGAM2FASN
Mangostin SCHEMBL29466055 1.00 MGAM (1.00) MGAMGAASIMGAM2FASN
Mangostin SCHEMBL676010 0.99 MGAM (0.98) MGAMGAASIMGAM2FASN
Mangostin SCHEMBL27218086 0.97 MGAM (0.93) MGAMGAASIMGAM2FASN
SCHEMBL29929598 0.92 MGAM (1.00) MGAMGAASIMGAM2FASN
SCHEMBL3742268 0.92 MGAM (1.00) MGAMGAASIMGAM2FASN
SCHEMBL30830372 0.92 MGAM (0.85) MGAMGAASIMGAM2FASN
SCHEMBL3750432 0.92 MGAM (0.85) MGAMGAASIMGAM2FASN
SCHEMBL29974819 0.92 MGAM (1.00) MGAMGAASIMGAM2FASN
Cowanin SCHEMBL29378034 0.92 MGAM (1.00) MGAMGAASIMGAM2FASN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2000 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122075440-A Nanoparticle loaded with alpha-mangostin and wolfberry polysaccharide as well as preparation method and application thereof 2026-05-26 CN claimed
CN-119790843-B Water transplanting method and device for rapid seedling raising of mangostin 广东环境保护工程职业学院 2026-05-19 CN claimed
CN-122055131-A Composition for sebum control 戴森运营私人有限公司 2026-05-15 CN claimed
EP-4724079-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION Stealth BioTherapeutics Inc. (US) 2026-04-15 EP claimed
EP-4719060-A1 PLANT TREATMENT METHOD Green Impulse (FR) 2026-04-08 EP claimed
EP-4719404-A2 METHODS FOR ADDRESSING INJECTION SITE REACTIONS ASSOCIATED WITH THE ADMINISTRATION OF BEVEMIPRETIDE Stealth BioTherapeutics Inc. (US) 2026-04-08 EP claimed
US-20260048096-A1 METHODS AND COMPOSITIONS FOR PRESERVING THE RETINAL OUTER NUCLEAR LAYER (ONL), PHOTORECEPTORS, AND RETINAL THICKNESS STEALTH BIOTHERAPEUTICS INC. (US) 2026-02-19 US claimed
EP-3727435-B1 BIVALENT NUCLEIC ACID LIGANDS AND USES THEREFOR UNIV CARNEGIE MELLON (US) 2026-02-18 EP claimed
US-20250302797-A1 COMBINATION THERAPIES FOR TREATING INFLAMMATION FLAGSHIP PIONEERING INNOVATIONS VI LLC (US) 2025-10-02 US claimed
EP-4583860-A1 INHIBITORS OF THE CERAMIDE METABOLIC PATHWAY FOR OVERCOMING IMMUNOTHERAPY RESISTANCE IN CANCER Institut National de la Santé et de la Recherche Médicale (FR) 2025-07-16 EP claimed
US-20040228884-A1 Ion-pair delivery system for cosmetic and pharmaceutical compositions GUPTA SHYAM K (US) 2004-11-18 US claimed
US-20040219124-A1 Cosmetic and Pharmaceutical Masks Based on Ion-Pair Delivery System GUPTA SHYAM K (US) 2004-11-04 US claimed
US-20040208902-A1 Controlled-release nano-diffusion delivery systems for cosmetic and pharmaceutical compositions GUPTA SHYAM K (US) 2004-10-21 US claimed
US-20040161435-A1 Skin Firming Anti-Aging Cosmetic Mask Compositions GUPTA SHYAM K (US) 2004-08-19 US claimed
US-20040156873-A1 Topically Bioavailable Acne and Rosacea Treatment Compositions GUPTA SHYAM K (US) 2004-08-12 US claimed
US-20040146539-A1 Topical Nutraceutical Compositions with Selective Body Slimming and Tone Firming Antiaging Benefits GUPTA SHYAM K (US) 2004-07-29 US claimed
US-20030138467-A1 Methods for improving the aesthetic appearance of skin AVON PRODUCTS, INC. (US) 2003-07-24 US claimed
CN-1416806-A Local composition with undifferentiated plant seed cell and ifs usage EWEN PRODUCTS CO (US) 2003-05-14 CN claimed
EP-0496349-B1 Coating solution for preventing adhesion of polymer scale and method for its use SHINETSU CHEMICAL CO (JP) 1996-04-10 EP claimed
EP-0496349-A1 Coating solution for preventing adhesion of polymer scale and method for its use SHIN-ETSU CHEMICAL CO., LTD. (JP) 1992-07-29 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260048096-A1 METHODS AND COMPOSITIONS FOR PRESERVING THE RETINAL OUTER NUCLEAR LAYER (ONL), PHOTORECEPTORS, AND RETINAL THICKNESS NR2E3, ALDH1A2, PDE6D MGAM 4027/4885GAA 2896/4885SI 290/4885
US-20030138467-A1 Methods for improving the aesthetic appearance of skin CUTA, GLA, LRAT MGAM 1107/4885GAA 25/4885SI 1966/4885
US-20250302797-A1 COMBINATION THERAPIES FOR TREATING INFLAMMATION TNF, MMP8, TSLP MGAM 2278/4885GAA 1379/4885SI 1475/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.