SCHEMBL3555928

SCHEMBL3555928

Cn1c(C(F)(F)F)cc(=O)n(-c2ccc(Cl)c(S(=O)(=O)Cl)c2)c1=O

nearest known ligand 0.38

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.34
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 1/20 0.34
KMT2A Q03164 1/20 0.34
ATM Q13315 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
NOTUM Q6P988 1/20 0.32
MAPT P10636 2/20 0.31
PTGS1 P23219 1/20 0.31
PTGS2 P35354 1/20 0.31
TP53 P04637 1/20 0.31
AR P10275 1/20 0.30
BRD9 Q9H8M2 1/20 0.30
HTT P42858 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3545755 0.89 MMP2 (0.36) TSHRMEN1ALDH1A1KMT2AATM
SCHEMBL8936415 0.87 GSTO1 (0.41) TSHRMEN1ALDH1A1KMT2AATM
SCHEMBL8936370 0.87 MEN1 (0.39) TSHRMEN1ALDH1A1KMT2AATM
SCHEMBL3546133 0.84 MEN1 (0.31) TSHRMEN1ALDH1A1KMT2AATM
SCHEMBL8002260 0.84 AR (0.38) AR
SCHEMBL8936351 0.82 ALDH1A1 (0.32) TSHRMEN1ALDH1A1KMT2AATM
SCHEMBL13693064 0.82 PTGS1 (0.37) NOTUMMAPTPTGS1PTGS2AR
SCHEMBL8936368 0.82 ALDH1A1 (0.34) TSHRALDH1A1KMT2AL3MBTL1BRD9
SCHEMBL7833205 0.81 MEN1 (0.41) TSHRMEN1ALDH1A1KMT2AATM
SCHEMBL31442410 0.81 COMT (0.37) TSHRALDH1A1KMT2ANOTUMMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1613607-B1 BENZENESULPHONAMIDE DERIVATIVES AS HERBICIDES OR DESICCANT/DEFOLIANT COMPOUNDS BASF SE (DE) 2013-01-09 EP disclosed
US-7741485-B2 Benzenesulphonamide derivatives as herbicides or desiccant/defoliant compounds BASF AKTIENGESELLSCHAFT (DE) 2010-06-22 US disclosed
US-20060211577-A1 Benzenesulphonamide derivatives as herbicides or desiccant/defoliant compounds BASF AKTIENGESELLSCHAFT (DE) 2006-09-21 US disclosed
EP-1613607-A1 BENZENESULPHONAMIDE DERIVATIVES AS HERBICIDES OR DESICCANT/DEFOLIANT COMPOUNDS BASF Aktiengesellschaft (DE) 2006-01-11 EP disclosed
WO-2004089914-A1 BENZENESULPHONAMIDE DERIVATIVES AS HERBICIDES OR DESICCANT/DEFOLIANT COMPOUNDS BASF AKTIENGESELLSCHAFT (DE) 2004-10-21 WO disclosed
US-5486610-A HERBICIDE INTERMEDIATES UNIROYAL CHEMICAL COMPANY, INC. (US) 1996-01-23 US disclosed
US-5324854-A Herbicides UNIROYAL CHEMICAL COMPANY, INC. (US) 1994-06-28 US disclosed
EP-0598774-A1 BENZENESULFONAMIDE DERIVATIVES AS HERBICIDES UNIROYAL CHEMICAL COMPANY, Inc. (US) 1994-06-01 EP disclosed
WO-1993003019-A1 BENZENESULFONAMIDE DERIVATIVES AS HERBICIDES UNIROYAL CHEMICAL COMPANY, INC. (US) 1993-02-18 WO disclosed
US-5169430-A Herbicides UNIROYAL CHEMICAL COMPANY, INC. (US) 1992-12-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060211577-A1 Benzenesulphonamide derivatives as herbicides or desiccant/defoliant compounds CBR3, CBR1, CNPY2 TSHR 783/4885MEN1 4858/4885ALDH1A1 2179/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.