SCHEMBL8936370

SCHEMBL8936370

CNS(=O)(=O)c1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)ccc1Cl

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
GSTO1 P78417 1/20 0.36
MCL1 Q07820 4/20 0.34
TP53 P04637 1/20 0.33
MAPT P10636 1/20 0.33
ALDH1A1 P00352 2/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
LMNA P02545 1/20 0.33
GLA P06280 1/20 0.33
TSHR P16473 1/20 0.33
ATM Q13315 1/20 0.33
PIK3CD O00329 1/20 0.30
PIK3CA P42336 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3555928 0.87 TSHR (0.34) MEN1KMT2ATP53MAPTALDH1A1
SCHEMBL3625337 0.87 NPSR1 (0.32) SMN1; SMN2GSTO1MCL1TP53MAPT
SCHEMBL3545755 0.86 MMP2 (0.36) MEN1KMT2AMAPTALDH1A1L3MBTL1
SCHEMBL8936415 0.84 GSTO1 (0.41) MEN1KMT2ASMN1; SMN2GSTO1MAPT
SCHEMBL8936385 0.84 GSTO1 (0.45) MEN1KMT2ASMN1; SMN2GSTO1MAPT
SCHEMBL3546133 0.81 MEN1 (0.31) MEN1KMT2AALDH1A1L3MBTL1TSHR
SCHEMBL8936351 0.80 ALDH1A1 (0.32) MEN1KMT2ACYP1A2CYP2C19SMN1; SMN2
SCHEMBL8466103 0.80 MCL1 (0.36) MCL1TP53MAPTALDH1A1TSHR
SCHEMBL13693064 0.79 PTGS1 (0.37) MAPTNOTUM
SCHEMBL8936368 0.79 ALDH1A1 (0.34) KMT2ACYP1A2CYP2C19SMN1; SMN2GSTO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5486610-A HERBICIDE INTERMEDIATES UNIROYAL CHEMICAL COMPANY, INC. (US) 1996-01-23 US disclosed
US-5324854-A Herbicides UNIROYAL CHEMICAL COMPANY, INC. (US) 1994-06-28 US disclosed
EP-0598774-A1 BENZENESULFONAMIDE DERIVATIVES AS HERBICIDES UNIROYAL CHEMICAL COMPANY, Inc. (US) 1994-06-01 EP disclosed
WO-1993003019-A1 BENZENESULFONAMIDE DERIVATIVES AS HERBICIDES UNIROYAL CHEMICAL COMPANY, INC. (US) 1993-02-18 WO disclosed
US-5169430-A Herbicides UNIROYAL CHEMICAL COMPANY, INC. (US) 1992-12-08 US disclosed