Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.54 |
| ▸ | TRPC3 | Q13507 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL537426 | 0.88 | ALDH1A1 (0.49) | TP53ALDH1A1TSHRSMN1; SMN2HPGD | |
| SCHEMBL2083765 | 0.86 | ALDH1A1 (0.53) | ALDH1A1TSHRSMN1; SMN2HPGDHTT | |
| SCHEMBL31254695 | 0.85 | ALDH1A1 (0.47) | TP53ALDH1A1TSHRSMN1; SMN2HPGD | |
| SCHEMBL29864375 | 0.85 | TP53 (0.49) | TP53ALDH1A1TSHRSMN1; SMN2HPGD | |
| SCHEMBL13404460 | 0.84 | ALDH1A1 (0.47) | TP53THRBALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL7312763 | 0.82 | THRB (0.61) | ORAI1TRPC3TP53TRPC5THRB | |
| SCHEMBL3564656 | 0.82 | ALDH1A1 (0.45) | TP53THRBALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL17421894 | 0.80 | PTGES (0.62) | ALDH1A1TSHRSMN1; SMN2HPGDHTT | |
| SCHEMBL9091142 | 0.79 | PTGS2 (0.69) | TSHRALOX5PTGS1HDAC3HDAC4 | |
| SCHEMBL7242808 | 0.79 | ORAI1 (0.60) | ORAI1TRPC3TP53TRPC5THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7705029-B2 | Acrylonitrile derivatives for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2010-04-27 | — | — | US | disclosed |
| US-7705029-B2 | Acrylonitrile derivatives for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2010-04-27 | — | — | US | disclosed |
| EP-1732900-A4 | ACRYLONITRILE DERIVATIVES FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2007-12-12 | — | — | EP | disclosed |
| US-20070270478-A1 | ACRYLONITRILE DERIVATIVES FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2007-11-22 | — | — | US | disclosed |
| US-20070270478-A1 | ACRYLONITRILE DERIVATIVES FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2007-11-22 | — | — | US | disclosed |
| US-20070270478-A1 | ACRYLONITRILE DERIVATIVES FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2007-11-22 | — | — | US | disclosed |
| US-7202232-B2 | Acrylonitrile derivatives for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2007-04-10 | — | — | US | disclosed |
| US-7202232-B2 | Acrylonitrile derivatives for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2007-04-10 | — | — | US | disclosed |
| US-7202232-B2 | Acrylonitrile derivatives for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2007-04-10 | — | — | US | disclosed |
| EP-1732900-A2 | ACRYLONITRILE DERIVATIVES FOR INFLAMMATION AND IMMUNE-RELATED USES | Synta Pharmaceuticals Corporation (US) | 2006-12-20 | — | — | EP | disclosed |
| US-20050272699-A1 | Acrylonitrile derivatives for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. | 2005-12-08 | — | — | US | disclosed |
| WO-2005091752-A2 | ACRYLONITRILE DERIVATIVES FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2005-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272699-A1 | Acrylonitrile derivatives for inflammation and immune-related uses | IL1B, IL6, TLR4 | ORAI1 3017/4885TRPC3 1960/4885TP53 637/4885 |
| US-20070270478-A1 | ACRYLONITRILE DERIVATIVES FOR INFLAMMATION AND IMMUNE-RELATED USES | IL1B, IL6, TLR4 | ORAI1 3017/4885TRPC3 1960/4885TP53 637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.