SCHEMBL355787

SCHEMBL355787

CNc1ncnc2[nH]c(O)nc12

nearest known ligand 0.43

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ YTHDC1 Q96MU7 4/20 0.43
▸ YTHDF2 Q9Y5A9 2/20 0.43
▸ PDPK1 O15530 1/20 0.41
▸ CSF1R P07333 1/20 0.36
▸ ADORA3 P0DMS8 9/20 0.35
▸ MAP4K4 O95819 1/20 0.33
▸ ADORA1 P30542 4/20 0.33
▸ ADORA2A P29274 1/20 0.32
▸ ADORA2B P29275 1/20 0.32
▸ PDE4A P27815 1/20 0.31
▸ PDE4B Q07343 1/20 0.31
▸ PDE4C Q08493 1/20 0.31
▸ PDE4D Q08499 1/20 0.31
▸ EGFR P00533 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20420131 0.79 YTHDC1 (0.49) YTHDC1YTHDF2PDPK1CSF1RADORA3
SCHEMBL16682266 0.77 — —
SCHEMBL355788 0.76 GSK3B (0.41) YTHDC1YTHDF2PDPK1CSF1RADORA1
SCHEMBL29923950 0.76 GSK3B (0.41) YTHDC1YTHDF2PDPK1CSF1RADORA1
SCHEMBL10960612 0.76 — —
SCHEMBL10442146 0.75 NUDT1 (0.46) YTHDC1YTHDF2PDPK1CSF1RMAP4K4
SCHEMBL42336 0.75 PIK3CG (0.42) ADORA1ADORA2A
SCHEMBL8823861 0.75 — —
SCHEMBL21913 0.67 YTHDC1 (0.47) YTHDC1YTHDF2PDPK1CSF1RADORA3
SCHEMBL6272986 0.65 YTHDC1 (0.46) YTHDC1YTHDF2PDPK1CSF1RADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 640 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150211004-A1 RNAI-BASED THERAPIES FOR CARDIOMYOPATHIES, MUSCULAR DYSTROPHIES AND LAMINOPATHIES AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2015-07-30 — — US claimed
EP-2838541-A1 RNAI-BASED THERAPIES FOR CARDIOMYOPATHIES, MUSCULAR DYSTROPHIES AND LAMINOPATHIES Agency For Science, Technology And Research (SG) 2015-02-25 — — EP claimed
WO-2013158046-A1 RNAI-BASED THERAPIES FOR CARDIOMYOPATHIES, MUSCULAR DYSTROPHIES AND LAMINOPATHIES AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2013-10-24 — — WO claimed
EP-0570514-A4 METHYLENE PHOSPHONATE NUCLEOSIDE ANALOGS AND OLIGONUCLEOTIDE ANALOGS MADE THEREFROM GILEAD SCIENCES INC (US) 1994-08-17 — — EP claimed
EP-0570514-A1 METHYLENE PHOSPHONATE NUCLEOSIDE ANALOGS AND OLIGONUCLEOTIDE ANALOGS MADE THEREFROM GILEAD SCIENCES, INC. (US) 1993-11-24 — — EP claimed
WO-1992013869-A1 METHYLENE PHOSPHONATE NUCLEOSIDE ANALOGS AND OLIGONUCLEOTIDE ANALOGS MADE THEREFROM GILEAD SCIENCES, INC. (US) 1992-08-20 — — WO claimed
US-12638452-B2 Nanopore assemblies and uses thereof OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2026-05-26 — — US disclosed
CN-122029282-A Novel aptamers to EphA2 (hepaplatin receptor 2 a) 阿普塔德尔治疗公司 2026-05-12 — — CN disclosed
US-12606814-B2 Oligonucleotide probes and uses thereof CARIS SCIENCE, INC. (US) 2026-04-21 — — US disclosed
US-20260078383-A1 RNA NANOSTRUCTURES AND METHODS OF MAKING AND USING RNA NANOSTRUCTURES UNIV ARIZONA STATE (US) 2026-03-19 — — US disclosed
US-12577627-B2 Selective detection of different dengue virus RNA serotypes using tandem toehold-mediated displacement reactions ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONE STATE UNIVERSITY (US) 2026-03-17 — — US disclosed
US-20260041702-A1 AGENTS THAT INHIBIT CCN LIGAND-INDUCED SIGNALLING FOR TREATING DISEASE TRIBUNE THERAPEUTICS AB (SE) 2026-02-12 — — US disclosed
US-20260014278-A1 HYBRID PEPTIDE DENDRIMER SYSTEMS AND EXTRAHEPATIC DELIVERY NUNTIUS THERAPEUTICS LTD (GB) 2026-01-15 — — US disclosed
EP-0570514-A4 METHYLENE PHOSPHONATE NUCLEOSIDE ANALOGS AND OLIGONUCLEOTIDE ANALOGS MADE THEREFROM GILEAD SCIENCES INC (US) 1994-08-17 — — EP disclosed
EP-0570514-A1 METHYLENE PHOSPHONATE NUCLEOSIDE ANALOGS AND OLIGONUCLEOTIDE ANALOGS MADE THEREFROM GILEAD SCIENCES, INC. (US) 1993-11-24 — — EP disclosed
EP-0549686-A1 MODIFIED INTERNUCLEOSIDE LINKAGES GILEAD SCIENCES, INC. (US) 1993-07-07 — — EP disclosed
WO-1993009127-A1 ENHANCED TRIPLE-HELIX FORMATION DIRECTED BY OLIGONUCLEOTIDES COMPOSED OF 2'-DEOXY-7-DEAZAXANTHOSINE AND 2'-DEOXY-7-DEAZAGUANOSINE AND RELATED ANALOGS GILEAD SCIENCES, INC. (US) 1993-05-13 — — WO disclosed
WO-1992014842-A1 APTAMERS SPECIFIC FOR THROMBIN AND METHODS OF USE GILEAD SCIENCES, INC. (US) 1992-09-03 — — WO disclosed
WO-1992013869-A1 METHYLENE PHOSPHONATE NUCLEOSIDE ANALOGS AND OLIGONUCLEOTIDE ANALOGS MADE THEREFROM GILEAD SCIENCES, INC. (US) 1992-08-20 — — WO disclosed
WO-1992005186-A1 MODIFIED INTERNUCLEOSIDE LINKAGES GILEAD SCIENCES (US) 1992-04-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12577627-B2 Selective detection of different dengue virus RNA serotypes using tandem toehold-mediated displacement reactions DDX41, DDX5, DDX6 YTHDC1 302/4885YTHDF2 327/4885PDPK1 4470/4885
US-12606814-B2 Oligonucleotide probes and uses thereof CD63, FLT4, NCL YTHDC1 2138/4885YTHDF2 1769/4885PDPK1 3523/4885
US-20260041702-A1 AGENTS THAT INHIBIT CCN LIGAND-INDUCED SIGNALLING FOR TREATING DISEASE PKD2, CCNK, PKD1 YTHDC1 4133/4885YTHDF2 3421/4885PDPK1 159/4885
US-20260078383-A1 RNA NANOSTRUCTURES AND METHODS OF MAKING AND USING RNA NANOSTRUCTURES PDCD1, TIA1, NSUN2 YTHDC1 463/4885YTHDF2 691/4885PDPK1 1914/4885
US-12638452-B2 Nanopore assemblies and uses thereof FAM83A, SCNN1G, SCN3A YTHDC1 2793/4885YTHDF2 2486/4885PDPK1 2820/4885
US-20260014278-A1 HYBRID PEPTIDE DENDRIMER SYSTEMS AND EXTRAHEPATIC DELIVERY CD47, CD2BP2, CD40LG YTHDC1 797/4885YTHDF2 360/4885PDPK1 959/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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