SCHEMBL355847

SCHEMBL355847

CC(C)(C)OC(=O)c1ccc(N)cc1F

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.44
ALDH1A1 P00352 2/20 0.40
NR1H2 P55055 1/20 0.40
NR1H4 Q96RI1 1/20 0.37
MAPT P10636 3/20 0.37
CYP3A4 P08684 2/20 0.37
KDM4E B2RXH2 2/20 0.37
ESR2 Q92731 1/20 0.37
PTPN1 P18031 1/20 0.37
ADRB2 P07550 1/20 0.36
ADRB1 P08588 1/20 0.36
ADRB3 P13945 1/20 0.36
CRBN Q96SW2 1/20 0.36
LMNA P02545 1/20 0.36
TP53 P04637 1/20 0.36
ADORA3 P0DMS8 1/20 0.36
CHRM1 P11229 1/20 0.36
TBXA2R P21731 1/20 0.36
SLC6A2 P23975 1/20 0.36
PDE4A P27815 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31188312 0.88 KIF11 (0.44) GAANR1H2MAPTCA12CA1
SCHEMBL14505214 0.87 GAA (0.40) GAAALDH1A1NR1H2NR1H4MAPT
SCHEMBL591090 0.83 CES2 (0.55) GAAALDH1A1MAPTNR3C2CES2
SCHEMBL1186570 0.81 GAA (0.67) GAAALDH1A1NR1H2NR1H4MAPT
SCHEMBL3288448 0.81 ADRB2 (0.52) GAAALDH1A1NR1H2NR1H4MAPT
SCHEMBL17374982 0.81 EGFR (0.47) ALDH1A1MAPTESR2LMNACA12
SCHEMBL14859967 0.81 PDK2 (0.41) ALDH1A1MAPTNR3C2CES2CES1
SCHEMBL364243 0.81 GAA (0.66) GAAALDH1A1MAPTKDM4ECRBN
SCHEMBL7987024 0.81 GAA (0.44) GAAALDH1A1NR1H2NR1H4MAPT
SCHEMBL17253286 0.81 CA1 (0.40) CA12CA1CA2CA9CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 125 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4725944-A1 NEW METHOD FOR PREPARING OXOPYRIDINE COMPOUND, AND KEY INTERMEDIATE AND USE Chengdu Shibeikang Biomedical Technology Co., Ltd. (CN) 2026-04-15 EP disclosed
CN-116262736-B Novel oxo-pyridine compound and preparation method and application thereof 成都施贝康生物医药科技有限公司 2025-05-13 CN disclosed
US-12297207-B2 Maytansinoid derivatives, conjugates thereof, and methods of use REGENERON PHARMACEUTICALS, INC. (US) 2025-05-13 US disclosed
CN-115066417-B Factor XIa inhibitors 上海京新生物医药有限公司 2025-05-02 CN disclosed
CN-116283750-B Heterocyclic amide derivative and preparation method and application thereof 成都泰和伟业生物科技有限公司 2025-02-07 CN disclosed
US-12195490-B2 STRAD-binding agents and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-01-14 US disclosed
WO-2024251276-A1 NEW METHOD FOR PREPARING OXOPYRIDINE COMPOUND, AND KEY INTERMEDIATE AND USE 成都施贝康生物医药科技有限公司 2024-12-12 WO disclosed
CN-117800955-A 2-or 4-pyrone derivative, pharmaceutical composition, preparation method and application thereof 上海美悦生物科技发展有限公司 2024-04-02 CN disclosed
CN-116969918-A Fluoro substituted pyridone derivative and its pharmaceutical composition, preparation method and use 上海美悦生物科技发展有限公司 2023-10-31 CN disclosed
CN-116874387-A Novel preparation method of oxo-pyridine compound and key intermediate 成都施贝康生物医药科技有限公司 2023-10-13 CN disclosed
US-5955463-A ANTITUMOR, ANTIINFLAMMATORY, AND ANTIARTHRITIC AGENTS ZENECA LIMITED (GB) 1999-09-21 US disclosed
WO-1999037630-A1 OXAZOLIDINONE COMBINATORIAL LIBRARIES, COMPOSITIONS AND METHODS OF PREPARATION VERSICOR, INC. (US) 1999-07-29 WO disclosed
WO-1999001442-A1 TRIAZINE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS ZENECA LIMITED (GB) 1999-01-14 WO disclosed
US-5843942-A Aromatic amino ethers as pain relieving agents ZENECA LIMITED (GB) 1998-12-01 US disclosed
US-5444061-A Antitumor agents BRITISH TECHNOLOGY GROUP LIMITED (GB) 1995-08-22 US disclosed
US-5395838-A Aromatic aminomethyl substitutes compounds IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1995-03-07 US disclosed
US-5280027-A Quinazoline containing compound IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1994-01-18 US disclosed
US-5252573-A Quinazoline derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-10-12 US disclosed
WO-1992016512-A1 ANTI-CANCER COMPOUNDS BRITISH TECHNOLOGY GROUP PLC (GB) 1992-10-01 WO disclosed
US-5089499-A Anticarcinogenic agents; thymidylate synthetase inhibitors; antiallergens; psoriasis IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-02-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12297207-B2 Maytansinoid derivatives, conjugates thereof, and methods of use SLC10A1, HNMT, OGFR GAA 664/4885ALDH1A1 317/4885NR1H2 427/4885
US-12195490-B2 STRAD-binding agents and uses thereof STRAP, STRA6, PLAUR GAA 1155/4885ALDH1A1 3678/4885NR1H2 4091/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.